Association of CBS 844ins68, MTR A2756G and MTRR A66G gene polymorphisms with depression: A population-based study from North India

被引:1
作者
Dahal, Suresh [1 ]
Longkumer, Imnameren [1 ]
Bhattacharjee, Debashis [1 ]
Devi, Naorem Kiranmala [1 ]
机构
[1] Univ Delhi, Dept Anthropol, Lab Biochem & Mol Genet, Delhi 110007, India
来源
GENE REPORTS | 2023年 / 30卷
关键词
Depression; One -carbon metabolism; Cystathionine; -synthase; Methyltransferase; Methylatransferase reductase; Genetic polymorphism; FOLATE METABOLIC PATHWAY; ONE-CARBON METABOLISM; MTHFR C677T; HOMOCYSTEINE; RISK; SUSCEPTIBILITY; SCHIZOPHRENIA; DISEASE; A1298C;
D O I
10.1016/j.genrep.2022.101714
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Background: Depression is one of the major global health problem currently affecting about 350 million people worldwide. Its cause is a multi-factorial which involves a complex mechanism of social, physiological, and biological factors. Mutations of genes in one-carbon metabolic pathway such as cystathionine-beta-synthase (CBS 844ins68), methyltransferase (MTR A2756G) and methyltransferase reductase (MTRR A66G) have been impli-cated in various neurological disorders.Objective: In the present study, we attempted to understand the association of these gene polymorphisms with depression among a North Indian population.Methods: A total of 808 participants aged between 30-and 70 years of either sex were recruited through door-to-door household survey. Depression status was identified by administering BDI-II. Genotyping of the selected gene polymorphisms were performed following previously reported protocols.Results: The result revealed that only MTR A2756G gene polymorphism was significantly associated with mild depression [OR 1.65 (95 % CI: 0.05-2.62) p = 0.03] but not with moderate and severe depression among the studied population. Since CBS, MTR and MTRR genes are found in OCMP, MTR A2756G gene polymorphism was found to be associated with mild depression but not with CBS 844in68 and MTRR A66G gene polymorphisms in the present study. Conclusion: Identification of susceptible genes involved in depressive disorder and early screening for mild depression may create better opportunity for timely intervention and further improve the quality of life.
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共 33 条
[1]   One-carbon metabolism and depression [J].
Assies, Johanna ;
Pouwer, Francois .
BRITISH JOURNAL OF PSYCHIATRY, 2008, 193 (04) :344-344
[2]  
Beck AT., 1987, BECK DEPRESSION INVE
[3]   Folate, vitamin B12, homocysteine, and the MTHFR 677C→T polymorphism in anxiety and depression -: The Hordaland Homocysteine Study [J].
Bjelland, I ;
Tell, GS ;
Vollset, SE ;
Refsum, H ;
Ueland, PM .
ARCHIVES OF GENERAL PSYCHIATRY, 2003, 60 (06) :618-626
[4]   Homocysteine and folate metabolism in depression [J].
Bottiglieri, T .
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2005, 29 (07) :1103-1112
[5]   The genetics of folate metabolism and maternal risk of birth of a child with Down syndrome and associated congenital heart defects [J].
Coppede, Fabio .
FRONTIERS IN GENETICS, 2015, 6
[6]   The MTR 2756A>G polymorphism and maternal risk of birth of a child with Down syndrome: a case-control study and a meta-analysis [J].
Coppede, Fabio ;
Bosco, Paolo ;
Lorenzoni, Valentina ;
Migheli, Francesca ;
Barone, Concetta ;
Antonucci, Ivana ;
Stuppia, Liborio ;
Romano, Corrado ;
Migliore, Lucia .
MOLECULAR BIOLOGY REPORTS, 2013, 40 (12) :6913-6925
[7]   Folate, Homocysteine, Vitamin B12, and Polymorphisms of Genes Participating in One-Carbon Metabolism in Late-Onset Alzheimer's Disease Patients and Healthy Controls [J].
Coppede, Fabio ;
Tannorella, Pierpaola ;
Pezzini, Ilaria ;
Migheli, Francesca ;
Ricci, Giulia ;
Ienco, Elena Caldarazzo ;
Piaceri, Irene ;
Polini, Antonio ;
Nacmias, Benedetta ;
Monzani, Fabio ;
Sorbi, Sandro ;
Siciliano, Gabriele ;
Migliore, Lucia .
ANTIOXIDANTS & REDOX SIGNALING, 2012, 17 (02) :195-204
[8]   A Dynamic Approach to Depression Treatment Prediction Comment [J].
Drysdale, Andrew T. ;
Patel, Gaurav H. .
BIOLOGICAL PSYCHIATRY, 2022, 92 (07) :526-527
[9]   Correlation between cystathionine beta synthase gene polymorphisms, plasma homocysteine and idiopathic mental retardation in Indian individuals from Kolkata [J].
Dutta, Samikshan ;
Chatterjee, Arpita ;
Sinha, Swagata ;
Chattopadhyay, Anindita ;
Mukhopadhyay, Kanchan .
NEUROSCIENCE LETTERS, 2009, 453 (03) :214-218
[10]   Association of MTHFR, MTR, and MTRR polymorphisms with Parkinson's disease among ethnic Chinese in Taiwan [J].
Fong, Chin-Shih ;
Shyu, Hann-Yeh ;
Shieh, Jia-Ching ;
Fu, Yi-Ping ;
Chin, Ting-Yu ;
Wang, Hsiao-Wei ;
Cheng, Chun-Wen .
CLINICA CHIMICA ACTA, 2011, 412 (3-4) :332-338