Meta-review on Perforation Model of Subarachnoid Hemorrhage in Mice: Filament Material as a Possible Moderator of Mortality

被引：5

作者：

Alpdogan, Serdar ^{[1
]}

Sander, Timo ^{[1
]}

Zhang, Rui ^{[1
]}

Khan, Dilaware ^{[1
]}

Li, Xuanchen ^{[1
]}

Zhou, Huakang ^{[1
]}

Li, Ke ^{[1
]}

Nickel, Ann-Christin ^{[1
]}

Zheng, Baolong ^{[1
]}

Skryabin, Anastasiya ^{[1
]}

Schieferdecker, Simon ^{[1
]}

Hofmann, Bjoern B. ^{[1
]}

Donaldson, Daniel Maximilian ^{[1
]}

Cornelius, Jan Frederick ^{[1
]}

Haenggi, Daniel ^{[1
]}

Muhammad, Sajjad ^{[1
]}

机构：

[1] Heinrich Heine Univ, Univ Hosp Duesseldorf, Med Fac, Dept Neurosurg, Moorenstr 5, D-40225 Dusseldorf, Germany

来源：

TRANSLATIONAL STROKE RESEARCH | 2024年 / 15卷 / 01期

关键词：

Subarachnoid hemorrhage; SAH; Perforation model; Mouse; Mortality; MOUSE MODEL; METAANALYSIS;

D O I：

10.1007/s12975-022-01106-4

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Robust preclinical models are inevitable for researchers to unravel pathomechanisms of subarachnoidal hemorrhage (SAH). For the mouse perforation model of SAH, the goal of this meta-review was the determination of variances in mortality, SAH severity grade, and vasospasm, and their experimental moderators, as many researchers are facing with incomparable results. We searched on the databases PubMed, Embase, and Web of Science for articles describing in vivo experiments using the SAH perforation mouse model and measuring mortality, SAH grade, and/or vasospasm. After screening, 42 articles (total of 1964 mice) were included into systematic review and meta-analysis. Certain model characteristics were insufficiently reported, e.g., perforation location (not reported in six articles), filament (material (n = 15) and tip texture (n = 25)), mouse age (n = 14), and weight (n = 10). Used injective anesthetics and location of perforation showed large variation. In a random-effects meta-analysis, the overall animal mortality following SAH was 21.3% [95% CI: 17.5%, 25.7%] and increased with longer observational periods. Filament material significantly correlated with animal mortality (p = 0.024) after exclusion of hyperacute studies (time after SAH induction < 24 h). Reported mean SAH grade was 10.7 [9.6, 11.7] on the scale of Sugawara (J Neurosci Methods 167:327-34, 2008). Furthermore, mean diameter of large cerebral arteries after SAH was reduced by 27.6% compared to sham-operated non-SAH mice. Uniforming standards of experimental procedures and their reporting are indispensable to increase overall comparability.

引用

页码：16 / 29

页数：14

共 38 条

[1]

Bahor Zsanett, 2021, BMJ Open Sci, V5, pe100103, DOI 10.1136/bmjos-2020-100103

[2] How to perform a meta-analysis with R: a practical tutorial [J].