Dopamine-functionalized pectin-based Pickering emulsion as an oral drug delivery system

被引：24

作者：

Zhang, Jia-qi ^{[1
]}

Li, Hai-chao ^{[2
]}

Wang, Jie ^{[3
]}

Liu, Sha-sha ^{[1
]}

Li, Jun ^{[1
]}

Li, De-qiang ^{[1
]}

机构：

[1] Xinjiang Agr Univ, Coll Chem & Chem Engn, Xinjiang Key Lab Agr Chem & Biomat, Urumqi 830052, Xinjiang, Peoples R China

[2] Beijing Forestry Univ, Beijing Key Lab Lignocellulos Chem, Beijing 100083, Peoples R China

[3] Chinese Acad Sci, CAS Key Lab Colloid Interface & Chem Thermodynam, CAS Res Educ Ctr Excellence Mol Sci, Beijing Natl Lab Mol Sci BNLMS,Inst Chem, Beijing 100190, Peoples R China

来源：

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS | 2023年 / 673卷

基金：

中国国家自然科学基金;

关键词：

Pectin; Dopamine; Pickering emulsion; Drug delivery system; Indomethacin; ENCAPSULATION; STABILITY; RELEASE; COMPLEX;

D O I：

10.1016/j.colsurfa.2023.131807

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Pickering emulsions can be utilized to improve the usage efficiency of water-insoluble drugs as oral drug delivery systems. The present study showed a series of dopamine-functionalized pectin-based Pickering emulsions for anti-inflammatory medication. The dopamine functionalization induced significant differences in wettability, zeta potential, particle size, and PDI value compared with the oxidized pectin. The resultant Pickering emulsions consequently had excellent stability and could be stored for 30 days. Moreover, the morphology of the dried Pickering emulsions was all nano-scale spherical particles. Indomethacin (IND) was used as a water-insoluble drug model. The resultant Pickering emulsion-based drug delivery system showed persistent release of IND for more than 12 h, high pH-responsiveness, and biocompatibility. All the results manifested the excellent potential of dopamine-functionalized pectin-based Pickering emulsions in drug delivery applications. The present work also provided a new approach to preparing Pickering emulsions from modified anionic polysaccharides for delivering the water-insoluble drugs.

引用

页数：11

共 51 条

[1] Bio-inspired polydopamine incorporated titania nanotube arrays for biomedical applications [J].