Artificial intelligence to assist specialists in the detection of haematological diseases

被引:0
作者
Diaz-del-Pino, Sergio [1 ]
Trelles-Martinez, Roberto [2 ]
Gonzalez-Fernandez, F. A. [3 ]
Guil, Nicolas [1 ]
机构
[1] Univ Malaga, Comp Architecture Dept, Malaga, Spain
[2] Fdn Alcorcon Univ Hosp Madrid, Hematol & Hemotherapy Serv, Madrid, Spain
[3] Clin San Carlos Univ Hosp Madrid, Hematol & Hemotherapy Serv, Madrid, Spain
关键词
Aiding clinicians; Hemograms; Machine learning; Classification; Artificial intelligence; Assist; Neural network; Anaemia; Complete blood count; Haematology; Diagnosis; THALASSEMIA;
D O I
10.1016/j.heliyon.2023.e15940
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Artificial intelligence, particularly the growth of neural network research and development, has become an invaluable tool for data analysis, offering unrivalled solutions for image generation, natural language processing, and personalised suggestions. In the meantime, biomedicine has been presented as one of the pressing challenges of the 21st century. The inversion of the age pyramid, the increase in longevity, and the negative environment due to pollution and bad habits of the population have led to a necessity of research in the methodologies that can help to mitigate and fight against these changes.The combination of both fields has already achieved remarkable results in drug discovery, cancer prediction or gene activation. However, challenges such as data labelling, architecture improvements, interpretability of the models and translational implementation of the proposals still remain. In haematology, conventional protocols follow a stepwise approach that includes several tests and doctor-patient interactions to make a diagnosis. This procedure results in sig-nificant costs and workload for hospitals.In this paper, we present an artificial intelligence model based on neural networks to support practitioners in the identification of different haematological diseases using only rutinary and inexpensive blood count tests. In particular, we present both binary and multiclass classification of haematological diseases using a specialised neural network architecture where data is studied and combined along it, taking into account the clinical knowledge of the problem, obtaining results up to 96% accuracy for the binary classification experiment. Furthermore, we compare this method against traditional machine learning algorithms such as gradient boosting decision trees and transformers for tabular data. The use of these machine learning techniques could reduce the cost and decision time and improve the quality of life for both specialists and patients while producing more precise diagnoses.
引用
收藏
页数:10
相关论文
共 40 条
[1]  
Agarap AF., 2018, PREPRINT
[2]   Neural Network Techniques for Cancer Prediction: A Survey [J].
Agrawal, Shikha ;
Agrawal, Jitendra .
KNOWLEDGE-BASED AND INTELLIGENT INFORMATION & ENGINEERING SYSTEMS 19TH ANNUAL CONFERENCE, KES-2015, 2015, 60 :769-774
[3]  
Akter F., 2018, J COMPUT COMMUN, V6, P76, DOI [10.4236/jcc.2018.64007, DOI 10.4236/JCC.2018.64007]
[4]   Identifying beta-thalassemia carriers using a data mining approach: The case of the Gaza Strip, Palestine [J].
AlAgha, Alaa S. ;
Faris, Hossam ;
Hammo, Bassam H. ;
Al-Zoubi, Ala M. .
ARTIFICIAL INTELLIGENCE IN MEDICINE, 2018, 88 :70-83
[5]   Machine learning and artificial intelligence in the service of medicine: Necessity or potentiality? [J].
Alsuliman, Tamim ;
Humaidan, Dania ;
Sliman, Layth .
CURRENT RESEARCH IN TRANSLATIONAL MEDICINE, 2020, 68 (04) :245-251
[6]   A comparative study of K-Nearest Neighbour, Support Vector Machine and Multi-Layer Perceptron for Thalassemia screening [J].
Amendolia, SR ;
Cossu, G ;
Ganadu, ML ;
Golosio, B ;
Masala, GL ;
Mura, GM .
CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS, 2003, 69 (1-2) :13-20
[7]  
Arik S.O., 2019, PREPRINT
[8]  
Arrizabalaga Amuch astegui B., 2017, ERITROPATOLOGIA
[9]   A renaissance of neural networks in drug discovery [J].
Baskin, Igor I. ;
Winkler, David ;
Tetko, Igor V. .
EXPERT OPINION ON DRUG DISCOVERY, 2016, 11 (08) :785-795
[10]   Laboratory diagnosis of thalassemia [J].
Brancaleoni, V. ;
Di Pierro, E. ;
Motta, I. ;
Cappellini, M. D. .
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 2016, 38 :32-40