Pupillary response changes in Graves' disease

Purpose: The aim of this study was to investigate pupillary contraction and dilatation response changes in Graves' disease. Materials and Methods: The patient group consisted of 55 euthyroid Graves patients and the control group consisted of 55 healthy individuals. Data from the right eyes of all participants were used. Static (scotopic, mesopic, photopic) and dynamic pupillometry measurements were performed with automatic pupillometry. The mean pupil dilatation speed was calculated according to dynamic measurements. Static measurements, dynamic measurements and the mean pupil dilatation speed data were compared between the patient and control groups.Results: There was no statistically significant difference between two groups in all static and dynamic values and the mean pupil dilatation speed. The mean scotopic pupil diameter was 5.41 & PLUSMN;0.776 mm in Graves' group and 5.55 & PLUSMN;0.747 mm in the control group. The mean mesopic pupil diameter was 4.39 & PLUSMN;0.721 in Graves' group and 4.17 & PLUSMN;0.640 mm in the control group. The mean photopic pupil diameter was 3.45 & PLUSMN;0,549 mm in Graves' group and 3.29 & PLUSMN;0.679 mm in the control group. The mean dynamic pupil diameter 0th second was 3, 54 & PLUSMN;0.541 mm in Graves' group and 3.48 & PLUSMN;0.708 mm in the control group. The mean speed of pupil dilatation at 18th second was 0.116 & PLUSMN;0.031 mm/sec in Graves' group and 0.128 & PLUSMN;0.040 mm/sec in the control group. Age was found to be an independent factor on pupillary parameters.Conclusion: The pupillary parameters of patients with euthyroid hormone levels were not affected. While pupillary responses appeared not to be affected in the case of euthyroidism, more studies including patients with hypothyroidism and hyperthyroidism are needed.