The Future of Vestibular Schwannoma Management

被引：1

作者：

Moore, Lindsay Scott ^{[1
]}

Stankovic, Konstantina M. ^{[1
,2
,3
]}

机构：

[1] Stanford Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 801 Welch Rd, Palo Alto, CA 94304 USA

[2] Stanford Univ, Sch Med, Dept Neurosurg, 453 Quarry Rd, Palo Alto, CA 94304 USA

[3] 801 Welch Rad, Palo Alto, CA 94304 USA

来源：

OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA | 2023年 / 56卷 / 03期

关键词：

Vestibular schwannoma; Neurofibromatosis type 2 (NF2); Human induced pluripotent stem cell models (hiPSC); Biomarkers; Fluorescence-guided surgery; Immunotherapy; Adoptive cell therapy; Gene therapy;

D O I：

10.1016/j.otc.2023.02.018

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

center dot The ultimate goal for the future of vestibular schwannoma (VS) management is personal-ized, precision medicine.center dot Innovations that will define the future of the diagnosis, prognosis, and monitoring of VS include biomarker identification using liquid biopsy of the blood and inner ear, artificial in-telligence algorithms, intracochlear endomicroscopy, advanced targeted imaging strate-gies, gene editing, next-generation sequencing techniques, and patient-derived cellular models of VS and inner ear.center dot Advances that will revolutionize future treatment paradigms of VS include ultra high dose rate radioterhapy, surgery guided by targeted molecular imaging, novel and repurposed targeted therapeutics, immunotherapies such as checkpoint inhibitors, adoptive T cell therapies, and tumor vaccines, and both in vivo and ex vivo gene therapeutic strategies.

引用

页码：611 / 622

页数：12

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