Effect of sound-induced repeated stress on the development of pain and inflammation in the temporomandibular joint of female and male rats

被引:2
作者
Zanelatto, Fernanda Barchesi [1 ]
Vieira, Willians Fernando [2 ,3 ]
Nishijima, Catarine Massucato [1 ]
Sartori, Cesar Renato [1 ]
Parada, Carlos Amilcar [1 ]
Tambeli, Claudia Herrera [1 ,4 ]
机构
[1] Univ Estadual Campinas, Inst Biol, Dept Struct & Funct Biol, Campinas, SP, Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Sao Paulo, Brazil
[3] Harvard Med Sch, Dept Psychiat, Boston, MA USA
[4] Univ Estadual Campinas, Inst Biol, Dept Struct & Funct Biol, Rua Carl Von Linnaeus,Cidade Univ Zeferino Vaz Box, BR-13083864 Campinas, SP, Brazil
关键词
inflammation; nociception; repeated stress; temporomandibular joint; PITUITARY-ADRENAL AXIS; FORMALIN TEST; INDUCED INCREASE; ACTIVATION; RECEPTORS; PROPRANOLOL; EXPRESSION; MICE; TMD; BETA(2)-ADRENERGIC-RECEPTOR;
D O I
10.1111/eos.12936
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Temporomandibular disorder (TMD) is a common painful condition of the temporomandibular joint (TMJ) and associated structures. Stress is a significant risk factor for developing this painful condition that predominantly affects women. This study aimed to test the hypothesis that stress increases the risk of developing TMJ pain by facilitating inflammatory mechanisms in female and male rats. To test this hypothesis, we evaluated TMJ carrageenan-induced expression of pro-inflammatory cytokines and migration of inflammatory cells and TMJ formalin-induced nociception in female and male rats submitted to a repeated stress protocol induced by sound. We found that sound-induced repeated stress facilitates TMJ inflammation and contributes to TMJ nociception development equally in females and males. We conclude that stress is a risk factor for developing painful TMJ conditions in males and females, at least in part, by favoring the inflammatory process similarly in both sexes.
引用
收藏
页数:12
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