Posterior capsule opacification (PCO) remains the most common cause of vision loss post cataract surgery. The clinical management of PCO formation is limited to either physical impedance of residual lens epithelial cells (LECs) by implantation of specially designed intraocular lenses (IOL) or laser ablation of the opaque posterior capsular tissues; however, these strategies cannot fully eradicate PCO and are associated with other ocular complications. In this review, we critically appraise recent advances in conventional and nanotechnology-based drug delivery approaches to PCO prophylaxis. We focus on long-acting dosage forms, including drug-eluting IOL, injectable hydrogels, nanoparticles and implants, highlighting analysis of their controlled drug-release properties (e.g., release duration, maximum drug release, drug-release half-life). The rational design of drug delivery systems by considering the intraocular environment, issues of initial burst release, drug loading content, delivery of drug combination and long-term ocular safety holds promise for the development of safe and effective pharmacological applications in anti-PCO therapies.
机构:
Univ Texas SW Med Ctr Dallas, Dept Surg, Dallas, TX 75390 USA
Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Biochem & Mol Biol, Newark, NJ 07103 USAUniv Texas SW Med Ctr Dallas, Dept Surg, Dallas, TX 75390 USA
Awasthi, Niranjan
Guo, Suqin
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Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Ophthalmol, Newark, NJ 07103 USAUniv Texas SW Med Ctr Dallas, Dept Surg, Dallas, TX 75390 USA
Guo, Suqin
Wagner, B. J.
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Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Biochem & Mol Biol, Newark, NJ 07103 USA
Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Ophthalmol, Newark, NJ 07103 USAUniv Texas SW Med Ctr Dallas, Dept Surg, Dallas, TX 75390 USA
机构:
Washington Univ, Sch Med, Dept Ophthalmol & Visual Sci, St Louis, MO 63110 USA
Washington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USAWashington Univ, Sch Med, Dept Ophthalmol & Visual Sci, St Louis, MO 63110 USA
Beebe, David C.
Shui, Ying-Bo
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Washington Univ, Sch Med, Dept Ophthalmol & Visual Sci, St Louis, MO 63110 USAWashington Univ, Sch Med, Dept Ophthalmol & Visual Sci, St Louis, MO 63110 USA
Shui, Ying-Bo
Siegfried, Carla J.
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Washington Univ, Sch Med, Dept Ophthalmol & Visual Sci, St Louis, MO 63110 USAWashington Univ, Sch Med, Dept Ophthalmol & Visual Sci, St Louis, MO 63110 USA
Siegfried, Carla J.
Holekamp, Nancy M.
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Washington Univ, Sch Med, Dept Ophthalmol & Visual Sci, St Louis, MO 63110 USA
Pepose Vis Inst, Chesterfield, MO USAWashington Univ, Sch Med, Dept Ophthalmol & Visual Sci, St Louis, MO 63110 USA
Holekamp, Nancy M.
Bai, Fang
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Washington Univ, Sch Med, Dept Ophthalmol & Visual Sci, St Louis, MO 63110 USAWashington Univ, Sch Med, Dept Ophthalmol & Visual Sci, St Louis, MO 63110 USA
机构:
Ophthalm Consultants Long Isl, Garden City, NY USA
NYU, Dept Ophthalmol, 550 1St Ave, New York, NY 10016 USAOphthalm Consultants Long Isl, Garden City, NY USA
Donnenfeld, Eric
Holland, Edward
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Univ Cincinnati, Cincinnati Eye Inst, Dept Ophthalmol, Cornea Serv, Cincinnati, OH USAOphthalm Consultants Long Isl, Garden City, NY USA
机构:
Univ Texas SW Med Ctr Dallas, Dept Surg, Dallas, TX 75390 USA
Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Biochem & Mol Biol, Newark, NJ 07103 USAUniv Texas SW Med Ctr Dallas, Dept Surg, Dallas, TX 75390 USA
Awasthi, Niranjan
Guo, Suqin
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h-index: 0
机构:
Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Ophthalmol, Newark, NJ 07103 USAUniv Texas SW Med Ctr Dallas, Dept Surg, Dallas, TX 75390 USA
Guo, Suqin
Wagner, B. J.
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h-index: 0
机构:
Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Biochem & Mol Biol, Newark, NJ 07103 USA
Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Ophthalmol, Newark, NJ 07103 USAUniv Texas SW Med Ctr Dallas, Dept Surg, Dallas, TX 75390 USA
机构:
Washington Univ, Sch Med, Dept Ophthalmol & Visual Sci, St Louis, MO 63110 USA
Washington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USAWashington Univ, Sch Med, Dept Ophthalmol & Visual Sci, St Louis, MO 63110 USA
Beebe, David C.
Shui, Ying-Bo
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Ophthalmol & Visual Sci, St Louis, MO 63110 USAWashington Univ, Sch Med, Dept Ophthalmol & Visual Sci, St Louis, MO 63110 USA
Shui, Ying-Bo
Siegfried, Carla J.
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h-index: 0
机构:
Washington Univ, Sch Med, Dept Ophthalmol & Visual Sci, St Louis, MO 63110 USAWashington Univ, Sch Med, Dept Ophthalmol & Visual Sci, St Louis, MO 63110 USA
Siegfried, Carla J.
Holekamp, Nancy M.
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Ophthalmol & Visual Sci, St Louis, MO 63110 USA
Pepose Vis Inst, Chesterfield, MO USAWashington Univ, Sch Med, Dept Ophthalmol & Visual Sci, St Louis, MO 63110 USA
Holekamp, Nancy M.
Bai, Fang
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Ophthalmol & Visual Sci, St Louis, MO 63110 USAWashington Univ, Sch Med, Dept Ophthalmol & Visual Sci, St Louis, MO 63110 USA
机构:
Ophthalm Consultants Long Isl, Garden City, NY USA
NYU, Dept Ophthalmol, 550 1St Ave, New York, NY 10016 USAOphthalm Consultants Long Isl, Garden City, NY USA
Donnenfeld, Eric
Holland, Edward
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cincinnati, Cincinnati Eye Inst, Dept Ophthalmol, Cornea Serv, Cincinnati, OH USAOphthalm Consultants Long Isl, Garden City, NY USA