Primary sinonasal lymphoma: A multi-institutional experience of clinical presentation, treatment, and outcomes

被引:6
作者
Eide, Jacob G. [1 ]
Kshirsagar, Rijul S. [1 ]
Birkenbeuel, Jack L. [2 ]
Abello, Eric H. [2 ]
Hobday, Sara [1 ]
Herzberg, Sabrina [1 ]
Wang, Beverly Y. [3 ]
Palmer, James N. [1 ]
Adappa, Nithin D. [1 ]
Kuan, Edward C. [2 ]
机构
[1] Univ Penn, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA
[2] Univ Calif Irvine, Dept Otolaryngol Head & Neck Surg, 101 City Dr South Orange, Orange, CA 92868 USA
[3] Univ Calif Irvine, Dept Pathol, Orange, CA 92868 USA
关键词
B cell; NK; T cell; outcomes; sinus tumors; skull base; POPULATION-BASED ANALYSIS; NATURAL KILLER/T-CELL; LARGE B-CELL; PARANASAL SINUSES; NASAL CAVITY; TRACT;
D O I
10.1002/alr.23102
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
BackgroundSinonasal lymphoma (SL) is a heterogeneous, underrecognized neoplastic disorder with limited outcomes data. We sought to better define outcomes by subtype and treatment at 2 referral centers over the past 2 decades. MethodsDemographics, clinicopathologic data, and treatment outcomes for patients treated for SL were queried from January 1, 2000 to December 31, 2021 at 2 tertiary academic medical centers. ResultsEighty-four patients were included, with an average age at diagnosis of 63.4 +/- 15 years. There were 34 females (40.5%). The majority of patients had an Eastern Cooperative Oncology Group (ECOG) score of <2 (76.2%) and the most common presenting symptom was facial swelling/pain (26.2%). The most common primary site was the nasal cavity (36.9%). Diffuse large B-cell lymphoma was the most common subtype (46.4%), followed by extranodal NK/T-cell lymphoma (17.9%). Chemotherapy was the most common treatment strategy (n = 59, 70.2%), followed by radiation therapy (n = 35, 41.7%) and immunotherapy (n = 24, 28.6%). Disease-specific survival rates at 1, 5, and 10 years were 85.7%, 73.6%, and 58.6%, respectively. Eighteen patients (21.4%) developed recurrence. On multivariate analysis, higher ECOG score (p < 0.0001) and history of head and neck radiation (p = 0.048) were associated with worse survival. Younger age was associated with greater risk of recurrence (p = 0.022) and male sex was associated with more treatment side effects (p = 0.012). ConclusionThis is the largest multi-institutional analysis of SL characteristics and outcomes. Our work suggests that, although disease control in the first 5 years is reasonable, 10-year outcomes remain challenging. Further studies are needed to investigate new treatment paradigms and risk stratification.
引用
收藏
页码:1492 / 1502
页数:11
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