Association of ACE1 I/D polymorphism and susceptibility to COVID-19 in Egyptian children and adolescents

被引：6

作者：

Boraey, Naglaa F. ^{[1
]}

Bebars, Marwa A. ^{[2
]}

Wahba, Ali A. ^{[3
]}

Abd El Lateef, Hanan M. ^{[4
]}

Attia, Mohamed Atif ^{[5
]}

Elsayed, Ahmed H. ^{[6
]}

Rashed, Khalid A. ^{[6
]}

Sorour, Ehab I. ^{[6
]}

Ahmed, Mohamed F. ^{[6
]}

Abd-Elrehim, Ghada A. B. ^{[1
]}

Soliman, Attia A. ^{[7
]}

Shehab, Mohamed M. M. ^{[7
]}

Elhindawy, Eman M. ^{[7
]}

Ibraheem, Ahmed A. A. ^{[7
]}

Shehata, Hassan ^{[7
]}

Yousif, Yousif M. ^{[7
]}

Hashem, Mustafa I. A. ^{[7
]}

Ahmed, Amani A. ^{[7
]}

Emam, Ahmed A. ^{[7
]}

Gameil, Dalia M. ^{[7
]}

Abdelhady, Eman M. ^{[7
]}

Abdelkhalek, Khalil ^{[8
]}

Morsi, Walaa E. M. A. ^{[8
]}

Selim, Dalia M. ^{[4
]}

Razek, Suzan A. ^{[4
]}

Ashraf, Bassem ^{[9
]}

Saleh, Ahmed S. E. ^{[10
]}

Eltrawy, Heba H. ^{[11
]}

Alanwar, Mohamed I. ^{[12
]}

Fouad, Rania A. ^{[13
,14
]}

Omar, Walaa E. ^{[14
]}

Nabil, Rehab M. ^{[15
]}

Abdelhamed, Mohamed R. ^{[16
]}

Ibrahim, Mona Yousri ^{[17
]}

Malek, Mai M. ^{[18
]}

Afify, Mona R. ^{[19
]}

Alharbi, Mohanned T. ^{[19
]}

Nagshabandi, Mohammed K. ^{[19
]}

Tarabulsi, Muyassar K. ^{[19
]}

Qashqary, Mohammed Esmail ^{[20
]}

Almoraie, Laila M. ^{[20
]}

Salem, Hanan F. ^{[21
]}

Rashad, Manal M. ^{[22
]}

El-Gaaly, Sonya A. A. ^{[23
]}

El-Deeb, Nahawand A. ^{[24
]}

Abdallah, Amany M. ^{[25
]}

Fakhreldin, Ahmed R. ^{[26
]}

Hassouba, Mohamed ^{[27
]}

Massoud, Yasmine M. ^{[28
]}

Attaya, Mona S. M. ^{[29
]}

机构：

[1] Sohag Univ, Fac Med, Dept Pediat, Sohag, Egypt

[2] Princess Alexandra Hosp, Dept Pediat, Harlow, England

[3] SSMC Sheikh Shakhbout Med City, Dept Pediat, Abu Dhabi, U Arab Emirates

[4] Ain Shams Univ, Fac Med, Dept Pediat, Cairo, Egypt

[5] SKMC Sheikh Khalifa Med City, Dept Pediat, Abu Dhabi, U Arab Emirates

[6] Al Azhar Univ, Fac Med Boys, Dept Pediat, Al Azhar, Egypt

[7] Zagazig Univ, Fac Med, Dept Pediat, Zagazig, Egypt

[8] Cairo Univ, Fac Med, Dept Pediat, Cairo, Egypt

[9] Mansoura Univ, Fac Med, Dept Otorhinolaryngol, Mansoura, Egypt

[10] Benha Univ, Fac Med, Dept Otorhinolaryngol, Banha, Egypt

[11] Al Azhar Univ, Fac Med Girls, Dept Chest Dis, Al Azhar, Egypt

[12] Zagazig Univ, Fac Med, Dept Cardiothorac Surg, Zagazig, Egypt

[13] AlMaarefa Univ, Coll Med, Dept Med Biochem, Riyadh, Saudi Arabia

[14] Zagazig Univ, Fac Med, Dept Med Biochem, Zagazig, Egypt

[15] Zagazig Univ, Fac Med, Dept Clin Pathol, Zagazig, Egypt

[16] Al Azhar Univ, Fac Med Boys, Dept Clin Pathol, Al Azhar, Egypt

[17] Al Azhar Univ, Fac Med Girls, Dept Clin Pathol, Al Azhar, Egypt

[18] Zagazig Univ, Fac Med, Dept Microbiol & Immunol, Zagazig, Egypt

[19] Univ Jeddah, Fac Med, Dept Med Microbiol & Parasitol, Jeddah 21589, Saudi Arabia

[20] Univ Jeddah, Univ Med Ctr, Dept Family & Community Med, Jeddah, Saudi Arabia

[21] Benha Univ, Fac Med, Dept Anesthesia, Banha, Egypt

[22] Zagazig Univ, Fac Med, Dept Anesthesia, Zagazig, Egypt

[23] Ain Shams Univ, Fac Med, Dept Internal Med, Ain Shams, Egypt

[24] Zagazig Univ, Fac Med, Dept Internal Med, Zagazig, Egypt

[25] Zagazig Univ, Fac Med, Dept Family Med, Zagazig, Egypt

[26] Aswan Univ, Fac Med, Dept Pediat, Aswan, Egypt

[27] SUNY Downstate Hlth Sci Univ, Kings Cty Hosp, Dept Pediat, Brooklyn, NY USA

[28] Ain Shams Univ, Fac Med, Dept Trop Med, Ain Shams, Egypt

[29] Al Azhar Univ, Fac Med Girls, Dept Pediat, Al Azhar, Egypt

[30] Assiut Univ, Fac Med, Dept Pediat, Assiut, Egypt

来源：

PEDIATRIC RESEARCH | 2024年 / 96卷 / 05期

关键词：

CONVERTING-ENZYME GENE; INSERTION/DELETION POLYMORPHISM; ANGIOTENSIN; GENOTYPE; DISEASE;

D O I：

10.1038/s41390-023-02982-8

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Background: Given the sparse data on the renin-angiotensin system (RAS) and its biological effector molecules ACE1 and ACE2 in pediatric COVID-19 cases, we investigated whether the ACE1 insertion/deletion (I/D) polymorphism could be a genetic marker for susceptibility to COVID-19 in Egyptian children and adolescents.Methods: This was a case-control study included four hundred sixty patients diagnosed with COVID-19, and 460 well-matched healthy control children and adolescents. The I/D polymorphism (rs1799752) in the ACE1 gene was genotyped by polymerase chain reaction (PCR), meanwhile the ACE serum concentrations were assessed by ELISA.Results: The ACE1 D/D genotype and Deletion allele were significantly more represented in patients with COVID-19 compared to the control group (55% vs. 28%; OR = 2.4; [95% CI: 1.46-3.95]; for the DD genotype; P = 0.002) and (68% vs. 52.5%; OR: 1.93; [95% CI: 1.49-2.5] for the D allele; P = 0.032). The presence of ACE1 D/D genotype was an independent risk factor for severe COVID-19 among studied patients (adjusted OR: 2.6; [95% CI: 1.6-9.7]; P < 0.001.Conclusions: The ACE1 insertion/deletion polymorphism may confer susceptibility to SARS-CoV-2 infection in Egyptian children and adolescents.

引用

页码：1347 / 1354

页数：8

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