Extensions of the causal framework to Mendelian randomisation and gene-environment interaction

被引：1

作者：

Haworth, Claire M. A. ^{[1
]}

Wootton, Robyn E. ^{[1
,2
]}

机构：

[1] Univ Bristol, Sch Psychol Sci, Bristol, Avon, England

[2] Lovisenberg Diaconal Hosp, Nic Waals Inst, Oslo, Norway

来源：

BEHAVIORAL AND BRAIN SCIENCES | 2023年 / 46卷

关键词：

D O I：

10.1017/S0140525X22002205

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

In our commentary we ask whether we should ultimately endeavour to find the deep causes of behaviours? Then we discuss two extensions of the proposed framework: (1) Mendelian randomisation and (2) hypothesis-free gene-environment interaction (leveraging heterogeneity in genetic associations). These complementary methods help move us towards second-generation causal knowledge, ultimately understanding mechanistic pathways and identifying more effective intervention targets.

引用

页数：18

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