Characterization and Biological Activity of Native and Sulfated Noni (Morinda citrifolia Linn.) Pectin

被引：2
|
作者：
Santos, Denilton G. [1 ]
Cunha, Arcelina P. [1 ]
Ribeiro, Ana C. B. [1 ]
Brito, Debora H. A.
Alenca, Luciana M. R. [2 ]
Farias, Davi F. [3 ]
Carvalho, Ana F. F. U. [3 ]
Sousa, Joao A. C. [4 ]
Leal, Luzia K. A. M. [4 ]
Lopes, Nayara [5 ]
Linhares, Rosa E. C. [5 ]
Nozawa, Carlos [5 ]
Uchoa, Antonia F. J. [1 ]
Ribeiro, Maria E. N. P. [1 ]
Ricardo, Nagila M. P. S. [1 ]
机构：
[1] Univ Fed Ceara, Ctr Ciencias, Dept Quim Organ & Inorgan, Campus Pici, BR-60440900 Fortaleza, CE, Brazil
[2] Univ Fed Maranhao, Dept Fis, Lab Biofis & Biosistema, BR-65080805 Sao Luis, MA, Brazil
[3] Univ Fed Ceara, Ctr Ciencias, Dept Biol, Campus Pici, BR-60440900 Fortaleza, CE, Brazil
[4] Univ Fed Ceara, Fac Farm Odontol & Enfermagem, Dept Farm, BR-60430370 Fortaleza, CE, Brazil
[5] Univ Estadual Londrina, Ctr Ciencias Biol, Dept Microbiol, BR-86051990 Londrina, PR, Brazil
来源：
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2024年 / 35卷 / 04期
关键词：
noni pectin; cytotoxicity; HSV; ANTIVIRAL ACTIVITY; AGARICUS-BRASILIENSIS; POLYSACCHARIDE; PROLIFERATION; EXTRACTS;
D O I：
10.21577/0103-5053.20230156
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The aim of this work was to extract and characterize pectin from lyophilized noni pulp (Morinda citrifolia Linn.) at three different pHs using different extractor agents and to evaluate anti-viral activity. The extraction of high yield (acid extraction) was subjected to sulfation procedure. Fourier transform infrared spectroscopy and proton nuclear magnetic resonance analysis were used to calculate the degree of methylation of pectin from acid extraction and its sulfated derivative. The data obtained for the degree of methylation of noni pectin and sulfated pectin were 30.3 and 30.7, respectively. Pectin was subjected to acute oral toxicity testing in mice. The results showed that pectin had a pro-inflammatory effect, and sulfated pectin had an anti-inflammatory effect. Both pectins were also evaluated for herpes simplex virus activity in vitro, and although they successfully inhibited virus replication, the sulfated pectins were cytotoxic.
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页码：1 / 11
页数：11
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