Characterization and Biological Activity of Native and Sulfated Noni (Morinda citrifolia Linn.) Pectin

被引：2
|
作者：
Santos, Denilton G. [1 ]
Cunha, Arcelina P. [1 ]
Ribeiro, Ana C. B. [1 ]
Brito, Debora H. A.
Alenca, Luciana M. R. [2 ]
Farias, Davi F. [3 ]
Carvalho, Ana F. F. U. [3 ]
Sousa, Joao A. C. [4 ]
Leal, Luzia K. A. M. [4 ]
Lopes, Nayara [5 ]
Linhares, Rosa E. C. [5 ]
Nozawa, Carlos [5 ]
Uchoa, Antonia F. J. [1 ]
Ribeiro, Maria E. N. P. [1 ]
Ricardo, Nagila M. P. S. [1 ]
机构：
[1] Univ Fed Ceara, Ctr Ciencias, Dept Quim Organ & Inorgan, Campus Pici, BR-60440900 Fortaleza, CE, Brazil
[2] Univ Fed Maranhao, Dept Fis, Lab Biofis & Biosistema, BR-65080805 Sao Luis, MA, Brazil
[3] Univ Fed Ceara, Ctr Ciencias, Dept Biol, Campus Pici, BR-60440900 Fortaleza, CE, Brazil
[4] Univ Fed Ceara, Fac Farm Odontol & Enfermagem, Dept Farm, BR-60430370 Fortaleza, CE, Brazil
[5] Univ Estadual Londrina, Ctr Ciencias Biol, Dept Microbiol, BR-86051990 Londrina, PR, Brazil
来源：
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2024年 / 35卷 / 04期
关键词：
noni pectin; cytotoxicity; HSV; ANTIVIRAL ACTIVITY; AGARICUS-BRASILIENSIS; POLYSACCHARIDE; PROLIFERATION; EXTRACTS;
D O I：
10.21577/0103-5053.20230156
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The aim of this work was to extract and characterize pectin from lyophilized noni pulp (Morinda citrifolia Linn.) at three different pHs using different extractor agents and to evaluate anti-viral activity. The extraction of high yield (acid extraction) was subjected to sulfation procedure. Fourier transform infrared spectroscopy and proton nuclear magnetic resonance analysis were used to calculate the degree of methylation of pectin from acid extraction and its sulfated derivative. The data obtained for the degree of methylation of noni pectin and sulfated pectin were 30.3 and 30.7, respectively. Pectin was subjected to acute oral toxicity testing in mice. The results showed that pectin had a pro-inflammatory effect, and sulfated pectin had an anti-inflammatory effect. Both pectins were also evaluated for herpes simplex virus activity in vitro, and although they successfully inhibited virus replication, the sulfated pectins were cytotoxic.
引用
收藏
页码：1 / 11
页数：11
相关论文
共 50 条
  • [1] Antipsychotic-like activity of Noni (Morinda citrifolia Linn.) in mice
    Vijayapandi Pandy
    Megala Narasingam
    Zahurin Mohamed
    BMC Complementary and Alternative Medicine, 12
  • [2] Antipsychotic-like activity of Noni (Morinda citrifolia Linn.) in mice
    Pandy, Vijayapandi
    Narasingam, Megala
    Mohamed, Zahurin
    BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2012, 12
  • [3] The Role of Endophytic Fungi in the Anticancer Activity of Morinda citrifolia Linn. (Noni)
    Wu, Yougen
    Girmay, Sisay
    da Silva, Vitor Martins
    Perry, Brian
    Hu, Xinwen
    Tan, Ghee T.
    EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2015, 2015
  • [4] Anti-proliferative activity of Thai Noni (Morinda citrifolia linn.) leaf extract
    Thani, W.
    Luanratana, O.
    Siripong, P.
    Ruangwises, N.
    PLANTA MEDICA, 2008, 74 (09) : 970 - 970
  • [5] ANTIOXIDANT ACTIVITY OF THE PULP, SKIN AND SEEDS OF THE NONI (Morinda citrifolia Linn)
    Costa, Adriana Barbosa
    Campos De Oliveira, Adolfo Marcito
    De Oliveira E Silva, Ana Mara
    Mancini-Filho, Jorge
    De Lima, Alessandro
    REVISTA BRASILEIRA DE FRUTICULTURA, 2013, 35 (02) : 345 - 354
  • [6] Morinda citrifolia Linn. (Noni) and Its Potential in Obesity-Related Metabolic Dysfunction
    Inada, Aline Carla
    Figueiredo, Priscila Silva
    dos Santos-Eichler, Rosngela Aparecida
    Freitas, Karine de Cassia
    Hiane, Priscila Aiko
    de Castro, Alinne Pereira
    Avellaneda Guimaraes, Rita de Cassia
    NUTRIENTS, 2017, 9 (06):
  • [7] PROTECTION AGAINST SODIUM ARSENITE -INDUCED TOXICITY IN RATS BY NONI EXTRACT (MORINDA CITRIFOLIA LINN.)
    Ola-Davies, Olufunke E.
    Adeogun, Aina O.
    Opasina, Oladayo F.
    DRUG METABOLISM REVIEWS, 2014, 45 : 122 - 122
  • [8] Morinda citrifolia Linn (Noni): In vivo and in vitro reproductive toxicology
    Mueller, Juliane C.
    Botelho, Giuliana G. K.
    Bufalo, Aedra C.
    Boareto, Ana C.
    Rattmann, Yanna D.
    Martins, Elisangela S.
    Cabrini, Daniela A.
    Otuki, Michel F.
    Dalsenter, Paulo R.
    JOURNAL OF ETHNOPHARMACOLOGY, 2009, 121 (02) : 29 - 33
  • [9] Structural characterization of noni ( Morinda citrifolia L.) pectin and its inhibitory activity on pancreatic lipase
    Chang, Ziqing
    Gu, Chunhe
    Wang, Mengrui
    Chen, Junxia
    Zhou, Junping
    Yue, Mingzhe
    Zhang, Chao
    Liu, Fei
    Feng, Zhen
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2024, 283
  • [10] Effect of Morinda citrifolia Linn. Leaf Extracts on in vitro Lipase Activity
    Saraphanchotiwitthaya, Aurasorn
    Sripalakit, Pattana
    CHIANG MAI JOURNAL OF SCIENCE, 2014, 41 (5.1): : 1182 - 1193
12345