Associations between area-level arsenic exposure and adverse birth outcomes: An Echo-wide cohort analysis

被引：4

作者：

Lewis, Jonathan V. ^{[1
]}

Knapp, Emily A. ^{[1
]}

Bakre, Shivani ^{[1
]}

Dickerson, Aisha S. ^{[1
]}

Bastain, Theresa M. ^{[1
,2
]}

Bendixsen, Casper ^{[3
]}

Bennett, Deborah H. ^{[4
]}

Camargo, Carlos A. ^{[5
]}

Cassidy-Bushrow, Andrea E. ^{[6
]}

Colicino, Elena ^{[7
,8
]}

D'Sa, Viren ^{[9
]}

Dabelea, Dana ^{[10
]}

Deoni, Sean ^{[11
]}

Dunlop, Anne L. ^{[12
]}

Elliott, Amy J. ^{[13
,14
]}

Farzan, Shohreh F. ^{[1
]}

Ferrara, Assiamira ^{[15
]}

Fry, Rebecca C. ^{[16
]}

Hartert, Tina ^{[17
]}

Howe, Caitlin G. ^{[18
]}

Kahn, Linda G. ^{[19
,20
]}

Karagas, Margaret R. ^{[18
]}

Ma, Teng-Fei ^{[21
,22
]}

Koinis-Mitchell, Daphne ^{[9
]}

MacKenzie, Debra ^{[23
]}

Maldonado, Luis E. ^{[2
]}

Merced-Nieves, Francheska M. ^{[7
,24
]}

Neiderhiser, Jenae M. ^{[25
]}

Nigra, Anne E. ^{[26
]}

Niu, Zhongzheng ^{[2
]}

Nozadi, Sara S. ^{[27
]}

Rivera-Nunez, Zorimar ^{[28
,29
,30
]}

O'Connor, Thomas G. ^{[31
]}

Osmundson, Sarah ^{[32
]}

Padula, Amy M. ^{[33
]}

Peterson, Alicia K. ^{[15
]}

Sherris, Allison R. ^{[34
]}

Starling, Anne ^{[35
]}

Straughen, Jennifer K. ^{[6
]}

Wright, Rosalind J. ^{[7
,8
]}

Zhao, Qi ^{[36
]}

Kress, Amii M. ^{[1
,37
]}

机构：

[1] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[2] Univ Southern Calif, Dept Populat & Publ Hlth Sci, Los Angeles, CA USA

[3] Marshfield Clin Hlth Syst, Marshfield Clin Res Inst, Marshfield, WI USA

[4] Univ Calif Davis, Dept Publ Hlth Sci, Davis, CA 95616 USA

[5] Harvard Med Sch, Massachusetts Gen Hosp, Dept Emergency Med, Boston, MA USA

[6] Henry Ford Hlth, Dept Publ Hlth Sci, Detroit, MI USA

[7] Icahn Sch Med Mt Sinai, Dept Environm Med & Publ Hlth, New York, NY USA

[8] Icahn Sch Med Mt Sinai, Inst Expos Res, New York, NY USA

[9] Rhode Isl Hosp, Dept Pediat, Providence, RI USA

[10] Univ Colorado, Lifecourse Epidemiol Adipos & Diabet LEAD Ctr, Anschutz Med Campus, Denver, CO USA

[11] Bill & Melinda Gates Fdn, Seattle, WA USA

[12] Emory Univ, Sch Med, Dept Gynecol & Obstet, Atlanta, GA USA

[13] Avera Res Inst, Sioux Falls, SD USA

[14] Univ South Dakota, Dept Pediat, Sch Med, Vermillion, SD USA

[15] Kaiser Permanente Northern Calif, Div Res, Oakland, CA USA

[16] Univ N Carolina, Dept Environm Sci & Engn, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA

[17] Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN USA

[18] Dartmouth Coll, Geisel Sch Med, Hanover, NH 03755 USA

[19] NYU Grossman Sch Med, Dept Pediat, New York, NY USA

[20] NYU Grossman Sch Med, Dept Populat Hlth, New York, NY USA

[21] Michigan State Univ, Dept Epidemiol & Biostat, E Lansing, MI USA

[22] Univ New Mexico, Coll Pharm, Hlth Sci Ctr, Community Environm Hlth Program, Albuquerque, NM 87131 USA

[23] Icahn Sch Med Mt Sinai, Dept Pediat, New York, NY USA

[24] Penn State Univ, Dept Psychol, University Pk, PA USA

[25] Columbia Univ, Mailman Sch Publ Hlth, Dept Environm Hlth Sci, New York, NY USA

[26] Hlth Sci Ctr, Coll Pharm, Community Environm Hlth Program, Albuquerque, NM USA

[27] Rutgers Sch Publ Hlth, Dept Biostat & Epidemiol, New Brunswick, NJ USA

[28] Univ Rochester, Dept Psychiat, Rochester, NY USA

[29] Univ Rochester, Dept Neurosci, Rochester, NY USA

[30] Univ Rochester, Dept Obstet & Gynecol, Rochester, NY USA

[31] Vanderbilt Univ, Dept OB GYN, Sch Med, Nashville, TN USA

[32] Univ Calif San Francisco, Sch Med, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA USA

[33] Univ Washington, Dept Environm & Occupat Hlth Sci, Seattle, WA USA

[34] Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA

[35] Univ Tennessee, Hlth Sci Ctr, Coll Med, Dept Prevent Med, Memphis, TN USA

[36] Vanderbilt Univ, Med Ctr, Dept Pediat, Nashville, TN USA

[37] Johns Hopkins Bloomberg Sch Publ Hlth, 700 E Pratt St,Room 1022, Baltimore, MD 21202 USA

来源：

ENVIRONMENTAL RESEARCH | 2023年 / 236卷

基金：

美国国家卫生研究院;

关键词：

Arsenic; Drinking water; Contamination; Reproductive health; Water violations; Public water systems; DRINKING-WATER; GESTATIONAL-AGE; VIOLATIONS; PREGNANCY; PRETERM; HEALTH; WEIGHT;

D O I：

10.1016/j.envres.2023.116772

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Background: Drinking water is a common source of exposure to inorganic arsenic. In the US, the Safe Drinking Water Act (SDWA) was enacted to protect consumers from exposure to contaminants, including arsenic, in public water systems (PWS). The reproductive effects of preconception and prenatal arsenic exposure in regions with low to moderate arsenic concentrations are not well understood.Objectives: This study examined associations between preconception and prenatal exposure to arsenic violations in water, measured via residence in a county with an arsenic violation in a regulated PWS during pregnancy, and five birth outcomes: birth weight, gestational age at birth, preterm birth, small for gestational age (SGA), and large for gestational age (LGA).Methods: Data for arsenic violations in PWS, defined as concentrations exceeding 10 parts per billion, were obtained from the Safe Drinking Water Information System. Participants of the Environmental influences on Child Health Outcomes Cohort Study were matched to arsenic violations by time and location based on resi-dential history data. Multivariable, mixed effects regression models were used to assess the relationship between preconception and prenatal exposure to arsenic violations in drinking water and birth outcomes. Results: Compared to unexposed infants, continuous exposure to arsenic from three months prior to conception through birth was associated with 88.8 g higher mean birth weight (95% CI: 8.2, 169.5), after adjusting for individual-level confounders. No statistically significant associations were observed between any preconception or prenatal violations exposure and gestational age at birth, preterm birth, SGA, or LGA.Conclusions: Our study did not identify associations between preconception and prenatal arsenic exposure, defined by drinking water exceedances, and adverse birth outcomes. Exposure to arsenic violations in drinking water was associated with higher birth weight. Future studies would benefit from more precise geodata of water system service areas, direct household drinking water measurements, and exposure biomarkers.

引用

页数：10

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