Alteration of Gut Microbiome in Patients With Schizophrenia Indicates Links Between Bacterial Tyrosine Biosynthesis and Cognitive Dysfunction

被引：25

作者：

Thirion, Florence ^{[1
]}

Speyer, Helene ^{[2
]}

Hansen, Tue Haldor ^{[3
]}

Nielsen, Trine ^{[3
]}

Fan, Yong ^{[3
]}

Le Chatelier, Emmanuelle ^{[1
]}

Fromentin, Sebastien ^{[1
]}

Berland, Magali ^{[1
]}

Onate, Florian Plaza ^{[1
]}

Pons, Nicolas ^{[1
]}

Galleron, Nathalie ^{[1
]}

Levenez, Florence ^{[1
]}

Marko, Lajos ^{[11
,12
,13
,14
,15
,16
,17
]}

Birkner, Till ^{[11
,12
,13
,14
,15
]}

Jorgensen, Torben ^{[4
,5
,7
]}

Forslund, Sofia K. ^{[11
,12
,13
,14
,15
,17
,18
]}

Vestergaard, Henrik ^{[3
,8
]}

Hansen, Torben ^{[3
]}

Nordentoft, Merete ^{[2
]}

Mors, Ole ^{[9
,10
]}

Benros, Michael E. ^{[2
,6
]}

Pedersen, Oluf ^{[3
]}

Ehrlich, Stanislav D. ^{[1
,16
,19
]}

机构：

[1] Univ Paris Saclay, Inst Natl Rech Agr alimentat & environm, Jouy en josas, France

[2] Copenhagen Univ Hosp, Copenhagen Res Ctr Mental Hlth, Mental Hlth Ctr Copenha gen, Copenhagen, Denmark

[3] Novo Nordisk Fdn, Fac Hlth & Med Sci, Ctr Basic Metab Res, Hellerup, Denmark

[4] Bispebjerg & Frederiksberg Hosp, Ctr Clin Res & Prevent, Frederiksberg, Denmark

[5] Univ Copenhagen, Fac Med Sci, Dept Publ Hlth, Copenhagen, Denmark

[6] Univ Copenhagen, Fac Hlth & Med Sci, Dept Immunol & Microbiol, Copenhagen, Denmark

[7] Aalborg Univ, Fac Med, Aalborg, Denmark

[8] Bornholms Hosp, Dept Med HV, Ronne, Germany

[9] Aarhus Univ Hosp, Psychosis Res Unit, Risskov, Denmark

[10] Lundbeck Fdn Initiat Integrat Psychiat Res, iPSYCH OM, Aarhus, Denmark

[11] Charite Univ Med Berlin, Expt & Clin Res Ctr, Max Delbruck Ctr Mol Med, Berlin, Germany

[12] Charite Univ Med Berlin, Berlin, Germany

[13] Free Univ Berlin, Berlin, Germany

[14] Humboldt Univ, Berlin Inst Hlth, Berlin, Germany

[15] Helmholtz Assoc, Max Delbruck Ctr Mol Med, Berlin, Germany

[16] Partner Site Berlin, German Ctr Cardiovasc Res, Berlin, Germany

[17] Berlin Inst Hlth, Berlin, Germany

[18] European Mol Biol Lab, Struct & Computat Biol Unit, Heidelberg, Germany

[19] UCL, Dept Clin & Movement Neurosci, London, England

来源：

BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCE | 2023年 / 3卷 / 02期

关键词：

Case-control study; Cognition; Gut microbiome; Metagenomics; Schizophrenia; Tyrosine biosynthesis;

D O I：

10.1016/j.bpsgos.2022.01.009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

BACKGROUND: Schizophrenia (SCZ) is a heterogeneous neuropsychiatric disorder for which current treatment has insufficient efficacy and severe adverse effects. The modifiable gut microbiome might be a potential target for intervention to improve neurobiological functions through the gut-microbiome-brain axis. METHODS: In this case-control study, gut microbiota of 132 patients with SCZ and increased waist circumference were compared with gut microbiota of two age-and sex-matched control groups, composed of 132 healthy individuals and 132 individuals with metabolic syndrome. Shotgun sequencing was used to characterize fecal samples at the taxonomic and functional levels. Cognition of the patients with SCZ was evaluated using the Brief Assessment of Cognition instrument.RESULTS: SCZ gut microbiota differed significantly from those of healthy control subjects and individuals with metabolic syndrome in terms of richness and global composition. SCZ gut microbiota were notably enriched in Flavonifractor plautii, Collinsella aerofaciens, Bilophila wadsworthia, and Sellimonas intestinalis, while depleted in Faecalibacterium prausnitzii, Ruminococcus lactaris, Ruminococcus bicirculans, and Veillonella rogosae. Functional potential of the gut microbiota accounted for 11% of cognition variability. In particular, the bacterial functional module for synthesizing tyrosine, a precursor for dopamine, was in SCZ cases positively associated with cognitive score (r = 0.34, q # .1).CONCLUSIONS: Overall, this study shows that the gut microbiome of patients with SCZ differs greatly from that of healthy control subjects or individuals with metabolic syndrome. Cognitive function of patients with SCZ is associated with the potential for gut bacterial biosynthesis of tyrosine, a precursor for dopamine, suggesting that gut microbiota might be an intervention target for alleviation of cognitive dysfunction in SCZ.

引用

页码：283 / 291

页数：9

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