Animal naming test is a simple and valid tool for detecting covert hepatic encephalopathy and predicting outcomes in Chinese-speaking regions: a preliminary study

被引：5

作者：

Huang, Chien-Hao ^{[1
,2
]}

Yu, Tung-Yang ^{[2
,3
]}

Tseng, Wei-En Johnny ^{[2
,4
,5
]}

Huang, Yu-Tung ^{[6
,7
]}

Chang, Shang-Hung ^{[2
,7
,8
]}

Hsieh, Sen-Yung ^{[1
,2
]}

Chien, Rong-Nan ^{[1
,2
]}

Amodio, Piero ^{[9
]}

机构：

[1] Chang Gung Mem Hosp, Linkou Med Ctr, Dept Gastroenterol & Hepatol, Div Hepatol, Taoyuan, Taiwan

[2] Chang Gung Univ, Coll Med, Taoyuan, Taiwan

[3] Chang Gung Mem Hosp, Dept Phys Med & Rehabil, Linkou, Taiwan

[4] Chang Gung Mem Hosp, Linkou Med Ctr, Dept Neurol, Sect Epilepsy, Taoyuan, Taiwan

[5] Chang Gung Univ, Coll Med, Taoyuan, Taiwan

[6] Chang Gung Mem Hosp, Ctr Big Data Analyt & Stat, Linkou Med Ctr, Dept Med Res & Dev, Taoyuan, Taiwan

[7] Chang Gung Univ Sci & Technol, Grad Inst Nursing, Taoyuan, Taiwan

[8] Chang Gung Mem Hosp, Linkou Med Ctr, Cardiovasc Div, Taoyuan, Taiwan

[9] Univ Padua, Dept Med, Padua, Italy

来源：

ANNALS OF MEDICINE | 2023年 / 55卷 / 01期

关键词：

Hepatic encephalopathy; verbal fluency; cirrhosis; PHES; ANT(1); MMSE; DIAGNOSIS; CIRRHOSIS; BURDEN;

D O I：

10.1080/07853890.2023.2236013

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background and aims: Hepatic encephalopathy (HE) implies high morbidity and mortality. The assessment of covert HE (CHE) [i.e. minimal HE (MHE) plus grade 1 HE] is often neglected in Taiwan. Therefore, the aim was to investigate the potential of the animal naming test (ANT(1 )and simplified ANT(1) (s-ANT(1))) for assessing CHE in Chinese-speaking regions, specifically Taiwan.Methods: A prospective cohort study was conducted, comprising 65 cirrhotic patients and 29 healthy controls (relatives of the patients). Patients were followed up every three months and censored after two years or until death. Hospitalization for overt HE (OHE) and mortality were considered. All subjects underwent ANT(1), psychometric HE score (PHES), and mini-mental state examination (MMSE). The patients underwent an electroencephalogram (EEG) to detect slowing indicative of MHE. Cut-off values for ANT(1) and s-ANT(1) were assessed by ROC analysis and Youden's index, considering CHE as a reference. The prognostic values for OHE and OHE-free survival were assessed.Results: Preliminary analysis confirmed that PHES = -4 is a good discriminant point for abnormal results. CHE was found in 29 patients: 9 had MHE (PHES = -4 or altered EEG) and 20 had grade 1 HE. ANT(1) and s-ANT(1) were found to have diagnostic values for CHE: AUC = 0.807, 0.786; cut off: 18 and 19, respectively. ANT(1 )and s-ANT(1) were found to have prognostic value for OHE, number of hospitalization episodes for OHE, and OHE recurrence-free survival.Conclusions: ANT(1) shows promise as a tool for CHE detection, quantification, and follow-up in Taiwan and other Chinese-speaking regions.

引用

页数：11