Effects of 2-Year Physical Activity and Dietary Intervention on Adrenarchal and Pubertal Development: The PANIC Study

被引:4
作者
Liimatta, Jani [1 ,2 ,10 ]
Fluck, Christa E. [2 ,3 ]
Mantyselka, Aino [1 ,4 ]
Hakkinen, Merja R. [5 ,6 ]
Auriola, Seppo [5 ]
Voutilainen, Raimo [1 ,4 ]
Jaaskelainen, Jarmo [1 ,4 ]
Lakka, Timo A. [7 ,8 ,9 ]
机构
[1] Univ Eastern Finland, Kuopio Pediat Res Unit KuPRU, Kuopio 70029, Finland
[2] Univ Bern, Dept Biomed Res DBMR, CH-3008 Bern, Switzerland
[3] Bern Univ Hosp, Inselspital, Pediat Endocrinol Diabetol & Metab, CH-3010 Bern, Switzerland
[4] Kuopio Univ Hosp, Dept Pediat, Kuopio 70029, Finland
[5] Univ Eastern Finland, Sch Pharm, Kuopio 70211, Finland
[6] Finnish Inst Hlth & Welf THL, Dept Hlth Secur, Kuopio 70701, Finland
[7] Univ Eastern Finland, Inst Biomed, Sch Med, Kuopio 70211, Finland
[8] Kuopio Univ Hosp, Dept Clin Physiol & Nucl Med, Kuopio 70210, Finland
[9] Kuopio Res Inst Exercise Med, Fdn Res Hlth Exercise & Nutr, Kuopio 70211, Finland
[10] Kuopio Univ Hosp, Kuopio Pediat Res Unit KuPRu, Dept Pediat, POB 100, FI-70029 Kuopio, Finland
基金
芬兰科学院;
关键词
adrenarche; puberty; DHEAS; lifestyle intervention; physical activity; diet; OBESE CHILDREN; WEIGHT-GAIN; PREMATURE; PROFILES; HISTORY; PATTERN; PLASMA; SERUM;
D O I
10.1210/clinem/dgad367
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Context Childhood overweight has been linked to earlier development of adrenarche and puberty, but it remains unknown if lifestyle interventions influence sexual maturation in general populations. Objective To investigate if a 2-year lifestyle intervention influences circulating androgen concentrations and sexual maturation in a general population of children. Methods We conducted a 2-year physical activity and dietary intervention study in which 421 prepubertal and mostly normal-weight 6- to 9-year-old children were allocated either to a lifestyle intervention group (119 girls, 132 boys) or a control group (84 girls, 86 boys). The main outcome measures were serum dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), androstenedione (A4), and testosterone concentrations, and clinical adrenarchal and pubertal signs. Results The intervention and control groups had no differences in body size and composition, clinical signs of androgen action, and serum androgens at baseline. The intervention attenuated the increase of DHEA (P = .032), DHEAS (P = .001), A4 (P = .003), and testosterone (P = .007) and delayed pubarche (P = .038) in boys but it only attenuated the increase of DHEA (P = .013) and DHEAS (P = .003) in girls. These effects of lifestyle intervention on androgens and the development of pubarche were independent of changes in body size and composition, but the effects of intervention on androgens were partly explained by changes in fasting serum insulin. Conclusion A combined physical activity and dietary intervention attenuates the increase of serum androgen concentrations and sexual maturation in a general population of prepubertal and mostly normal-weight children, independently of changes in body size and composition.
引用
收藏
页码:E1587 / E1597
页数:11
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