Copper-Catalyzed Consecutive Ullmann, Decarboxylation, Oxidation, and Dehydration Reaction for Synthesis of Pyrrolo or Pyrido[1,2-a]imidazo[1,2-c]quinazolines

被引：5

作者：

Jiang, Weidong ^{[1
]}

Li, Ye ^{[1
]}

Liu, Jian-Quan ^{[1
]}

Wang, Xiang-Shan ^{[1
]}

机构：

[1] Jiangsu Normal Univ, Sch Chem & Mat Sci, Jiangsu Key Lab Green Synth Funct Mat, Xuzhou 221116, Jiangsu, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 27期

关键词：

QUINAZOLIN-4(3H)-ONES; CANCER; CYCLIZATION; GEFITINIB; LAPATINIB; ERLOTINIB; ANALOGS; DESIGN; IODINE; SALTS;

D O I：

10.1021/acs.orglett.3c01873

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A protocolfor a copper-catalyzed intermolecular cross-couplingcascade between 2-(2-bromoaryl)-1H-benzo[d]imidazole analogues and proline or pipecolic acid hasbeen developed. The developed protocol allows access to a varietyof synthetically useful N-fused pyrrolo or pyrido[1,2-a]imidazo[1,2-c]quinazoline scaffolds withhigh efficiency and good functional group compatibility. Proline orpipecolic acid plays a dual role in the reaction: as ligand and reactants.A mechanistically consecutive approach for the Ullmann coupling, decarboxylation,oxidation, and dehydration reaction process was presented.

引用

页码：5123 / 5127

页数：5

共 40 条

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