Hybrid imaging of prompt x-rays and induced positrons using a pinhole gamma camera during and after irradiation of protons

被引：1

作者：

Yamamoto, Seiichi ^{[1
]}

Watabe, Hiroshi ^{[2
]}

Nakanishi, Kohei ^{[3
]}

Yabe, Takuya ^{[4
]}

Yamaguchi, Mitsutaka ^{[4
]}

Kawachi, Naoki ^{[4
]}

Kamada, Kei ^{[5
]}

Yoshikawa, Akira ^{[5
]}

Islam, Md Rafiqul ^{[2
]}

Miyake, Masayasu ^{[2
]}

Tanaka, Kazuo S. ^{[1
]}

Kataoka, Jun ^{[1
]}

机构：

[1] Waseda Univ, Fac Sci & Engn, Tokyo, Japan

[2] Tohoku Univ, Cyclotron Radioisotope Ctr, Sendai, Japan

[3] Nagoya Univ, Grad Sch Med, Dept Integrated Hlth Sci, Nagoya, Japan

[4] Natl Inst Quantum Sci & Technol QST, Takasaki Inst Adv Quantum Sci, Fdn Quantum Technol Res Directorate, Chiba, Japan

[5] Tohoku Univ, New Ind Creat Hatchery Ctr NICHe, Sendai, Japan

来源：

PHYSICS IN MEDICINE AND BIOLOGY | 2023年 / 68卷 / 11期

关键词：

protons; prompt x-rays; pinhole x-ray camera; induced positron; imaging; RANGE VERIFICATION; EMISSION-TOMOGRAPHY; BEAMS; DELIVERY;

D O I：

10.1088/1361-6560/acd2a2

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Objective. Prompt x-ray imaging using a low-energy x-ray camera is a promising method for observing a proton beam's shape from outside the subject. Furthermore, imaging of positrons produced by nuclear reactions with protons is a possible method for observing the beam shape. However, it has not been possible to measure these two types of images with a single imaging system due to the limited imaging capability of existing systems. Imaging of both prompt x-rays and the distribution of positrons may compensate for the shortcomings of each method. Approach. We conducted imaging of the prompt x-ray using a pinhole x-ray camera during irradiation with protons in list mode. Then, after irradiation with protons, imaging of annihilation radiations from the produced positrons was conducted using the same pinhole x-ray camera in list mode. After this imaging, list-mode data were sorted to obtain prompt x-ray images and positron images. Main results. With the proposed procedure, we could measure both prompt x-ray images and induced positron images with a single irradiation by a proton beam. From the prompt x-ray images, ranges and widths of the proton beams could be estimated. The distributions of positrons were slightly wider than those of the prompt x-rays. From the time sequential positron images, we could derive the time activity curves of the produced positrons. Significance. Hybrid imaging of prompt x-rays and induced positrons using a pinhole x-ray camera was achieved. The proposed procedure would be useful for measuring prompt x-ray images during irradiation to estimate the beam structures as well as for measuring the induced positron images after irradiation to estimate the distributions and time activity curves of the induced positrons.

引用

页数：11

共 39 条

[1] Development of a low-energy x-ray camera for the imaging of secondary electron bremsstrahlung x-ray emitted during proton irradiation for range estimation [J].