Immunohistochemical Distribution and Neurochemical Characterization of Huntingtin-Associated Protein 1 Immunoreactive Neurons in the Adult Mouse Lingual Ganglia

被引：3

作者：

Islam, Md Nabiul ^{[1
]}

Sakurai, Yoshinori ^{[1
]}

Hiwaki, Yurie ^{[1
]}

Tarif, Abu Md Mamun ^{[1
]}

Afrin, Marya ^{[1
,2
]}

Meher, Mirza Mienur ^{[1
,3
,4
]}

Nozaki, Kanako ^{[1
]}

Masumoto, Koh Hei ^{[1
]}

Yanai, Akie ^{[1
,3
]}

Jahan, Mir Rubayet ^{[1
,2
]}

Shinoda, Koh ^{[1
]}

机构：

[1] Yamaguchi Univ, Grad Sch Med, Dept Neurosci, Div Neuroanat, 1-1-1 Minami Kogushi, Ube 7558505, Japan

[2] Bangladesh Agr Univ, Fac Vet Sci, Dept Anat & Histol, Mymensingh 2202, Bangladesh

[3] Yamaguchi Univ, Fac Med & Hlth Sci, Grad Sch Med, Dept Basic Lab Sci, 1-1-1 Minami Kogushi, Ube 7558505, Japan

[4] Bangabandhu Sheikh Mujibur Rahman Agr Univ, Fac Vet Med & Anim Sci, Dept Microbiol & Publ Hlth, Gazipur 1706, Bangladesh

来源：

BRAIN SCIENCES | 2023年 / 13卷 / 02期

基金：

日本学术振兴会;

关键词：

huntingtin-associated protein 1; lingual ganglia; neurodegeneration; neuroprotection; STIGMOID BODY; CYTOPLASMIC INCLUSION; NERVE-FIBERS; RAT-BRAIN; CELLS; EXPRESSION; RECEPTOR; HAP1; INTERACTS; TONGUE;

D O I：

10.3390/brainsci13020258

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Huntingtin-associated protein 1 (HAP1) is a determinant marker for the stigmoid body (STB), a neurocytoplasmic physiological inclusion. STB/HAP1 enriched areas in the brain/spinal cord are usually protected from neurodegenerative diseases, whereas the regions with tiny amounts or no STB/HAP1 are affected. In addition to the brain/spinal cord, HAP1 is highly expressed in the myenteric/submucosal plexuses of the enteric nervous system in the gastrointestinal tract. The tongue is attached to the pharynx by the hyoid bone as an extension of the gastrointestinal system. To date, the immunohistochemical distribution and neurochemical characterization of HAP1 have not been elucidated in the lingual ganglia. Using immunohistochemistry and light microscopy, our current study demonstrates the expression and immunohistochemical phenotype of HAP1 in the lingual ganglia of adult mice. We showed that HAP1 was profoundly distributed in the intralingual ganglion (ILG) and the ganglia near the root of the tongue (which we coined as "lingual root ganglion"; LRG). Neurons in ILG and LRG exhibited high coexpression of HAP1 with NOS or ChAT. Furthermore, most HAP1-immunoreactive neurons contained SP, CGRP, and VIP immunoreactivity in both ILG and LRG. The current results might serve as an essential base for future studies to elucidate the pathological/physiological functions of HAP1 in the lingual ganglia.

引用

页数：13

共 46 条

[1] Huntingtin-Associated Protein 1 in Mouse Hypothalamus Stabilizes Glucocorticoid Receptor in Stress Response [J].