Long-term outcomes of acute kidney injury in children

被引:5
作者
Schuermans, Art [1 ]
Van den Eynde, Jef [1 ]
Mekahli, Djalila [1 ,2 ]
Vlasselaers, Dirk [3 ,4 ,5 ]
机构
[1] Katholieke Univ Leuven, Dept Cellular & Mol Med, PKD Res Grp, Leuven, Belgium
[2] Univ Hosp Leuven, Dept Pediat Nephrol, Leuven, Belgium
[3] Univ Hosp Leuven, Dept Intens Care Med, Leuven, Belgium
[4] Katholieke Univ Leuven, Dept Cellular & Mol Med, Lab Intens Care Med, Leuven, Belgium
[5] Univ Hosp Leuven, Dept Intens Care Med, Herestr 49, B-3000 Leuven, Belgium
关键词
acute kidney injury; chronic kidney disease; hypertension; outcomes; paediatrics; ACUTE-RENAL-FAILURE; CRITICALLY-ILL CHILDREN; INTENSIVE-CARE-UNIT; RISK-FACTORS; FOLLOW-UP; CARDIAC-SURGERY; YOUNG-ADULTS; DISEASE; MORTALITY; CKD;
D O I
10.1097/MOP.0000000000001202
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Purpose of reviewAcute kidney injury (AKI) affects up to 35% of all critically ill children and is associated with substantial short-term morbidity and mortality. However, the link between paediatric AKI and long-term adverse outcomes remains incompletely understood. This review highlights the most recent clinical data supporting the role of paediatric AKI as a risk factor for long-term kidney and cardiovascular consequences. In addition, it stresses the need for long-term surveillance of paediatric AKI survivors.Recent findingsRecent large-scale studies have led to an increasing understanding that paediatric AKI is a significant risk factor for adverse outcomes such as hypertension, cardiovascular disease and chronic kidney disease (CKD) over time. These long-term sequelae of paediatric AKI are most often observed in vulnerable populations, such as critically ill children, paediatric cardiac surgery patients, children who suffer from severe infections and paediatric cancer patients.A growing body of research has shown that paediatric AKI is associated with long-term adverse outcomes such as CKD, hypertension and cardiovascular disease. Although therapeutic pathways tailored to individual paediatric AKI patients are yet to be validated, we provide a framework to guide monitoring and prevention in children at the highest risk for developing long-term kidney dysfunction.
引用
收藏
页码:259 / 267
页数:9
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