The role of CaMKK2 in Golgi-associated vesicle trafficking

被引：6

作者：

Kennedy, Grace ^{[1
]}

Gibson, Olivia ^{[1
]}

O'Hare, Daire T. ^{[1
]}

Mills, Ian G. ^{[1
,2
]}

Evergren, Emma ^{[1
]}

机构：

[1] Queens Univ Belfast, Patrick G Johnston Ctr Canc Res, 97 Lisburn Rd, Belfast BT9 7AE, Antrim, North Ireland

[2] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Surg Sci, Headley Way, Oxford OX3 9DU, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2023年 / 51卷 / 01期

基金：

英国科研创新办公室;

关键词：

KINASE; 2; CAMKK2; FUNCTIONAL-CHARACTERIZATION; REGULATORY MECHANISM; ANDROGEN RECEPTOR; PROSTATE-CANCER; COAT PROTEINS; CALMODULIN; CALCIUM; NETWORK; COMPLEX;

D O I：

10.1042/BST20220833

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) is a serine/threonine-protein kinase, that is involved in maintaining various physiological and cellular processes within the cell that regulate energy homeostasis and cell growth. CaMKK2 regulates glucose metabolism by the activation of downstream kinases, AMP-activated protein kinase (AMPK) and other calcium/calmodulin-dependent protein kinases. Consequently, its deregulation has a role in multiple human metabolic diseases including obesity and cancer. Despite the importance of CaMKK2, its signalling pathways and pathological mechanisms are not completely understood. Recent work has been aimed at broadening our understanding of the biological functions of CaMKK2. These studies have uncovered new interaction partners that have led to the description of new functions that include lipogenesis and Golgi vesicle trafficking. Here, we review recent insights into the role of CaMKK2 in membrane trafficking mechanisms and discuss the functional implications in a cellular context and for disease.

引用

页码：331 / 342

页数：12