Prevalence and concentration of Aflatoxin M1 in human breast milk in sub-Saharan Africa: a systematic review and meta-analysis, and cancer risk assessment

被引：7

作者：

Kabthymer, Robel Hussen ^{[1
]}

Kanno, Girum Gebremeskel ^{[1
]}

Aregu, Mekonen Birhane ^{[1
]}

Paixao, Susana ^{[2
]}

Belachew, Tefera ^{[3
]}

机构：

[1] Dilla Univ, Sch Publ Hlth, Dilla, Ethiopia

[2] Polytech Coimbra, Dept Environm Hlth, Coimbra Hlth Sch, Coimbra, Portugal

[3] Jimma Univ, Inst Hlth, Jimma, Ethiopia

来源：

INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH | 2023年 / 33卷 / 05期

关键词：

Aflatoxin; AFM1; breast milk; cancer; sub-Saharan Africa; NEONATAL CORD BLOOD; RICE ORYZA-SATIVA; PASTEURIZED MILK; NATURAL OCCURRENCE; OGUN STATE; EXPOSURE; M-1; MYCOTOXINS; SAMPLES; FOOD;

D O I：

10.1080/09603123.2022.2036330

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

This study aimed to assess the prevalence, concentration of AFM1 in human breast milk, and to determine the risk of cancer for infants in sub-Saharan Africa. A systematic literature search was performed using PubMed, CINAHL, Web of science, global health, Cochrane, and Google Scholar electronic databases. A random-effects model was used to estimate the pooled prevalence and concentration of AFM1 in breast milk. The meta-analysis of 8 articles containing 9 studies showed the pooled prevalence of AFM1 in breast milk to be 56.18% (95% CI: 29.65-82.71) and the pooled concentration to be 31.12 ng/L (95% CI: 25.97-36.25). The cancer risk assessment indicated for both male and female 1-month infants in Sierra Leone (HI > 1) is high, and all the rest of the infants are free of risk (HI < 1). The pooled prevalence and mean concentration of AFM1 in breast milk is high. Monitoring of AFB1 concentration of commonly used foods will be of high value in reducing the burden of AFM1.

引用

页码：491 / 507

页数：17

共 78 条

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