DDX41: exploring the roles of a versatile helicase

被引：2
作者：
Winstone, Lacey [1 ]
Jung, Yohan [1 ]
Wu, Yuliang [1 ]
机构：
[1] Univ Saskatchewan, Dept Biochem Microbiol & Immunol, Saskatoon, SK S7N 5E5, Canada
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2024年 / 52卷 / 01期
基金：
加拿大自然科学与工程研究理事会;
关键词：
ACUTE MYELOID-LEUKEMIA; I IFN PRODUCTION; CYCLIC-DI-AMP; FUNCTIONAL-CHARACTERIZATION; R-LOOP; FAMILY; MUTATIONS; VARIANTS; SENSOR; EXPRESSION;
D O I：
10.1042/BST20230725
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
DDX41 is a DEAD-box helicase and is conserved across species. Mutations in DDX41 have been associated with myeloid neoplasms, including myelodysplastic syndrome and acute myeloid leukemia. Though its pathogenesis is not completely known, DDX41 has been shown to have many cellular roles, including in pre-mRNA splicing, innate immune sensing, ribosome biogenesis, translational regulation, and R -loop metabolism. In this review, we will summarize the latest understandings regarding the various roles of DDX41, as well as highlight challenges associated with drug development to target DDX41. Overall, understanding the molecular and cellular mechanisms of DDX41 could help develop novel therapeutic options for DDX41 mutation-related hematologic malignancies.
引用
收藏
页码：395 / 405
页数：11
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