This Review provides an in-depth overview of carbon dioxide (CO2) capture, utilization, and sequestration (CCUS) technologies and their potential in global decarbonization efforts. The Review discusses the concept of CO2 utilization, including conversion to fuels, chemicals, and minerals as well as biological processes. It also explores the different types of CO2 sequestration, including geological, ocean, and mineral storage, and the associated challenges and opportunities such as regulatory issues and public acceptance. The Review highlights the potential of integrating CO2 CCUS technologies and presents case studies of successful projects. The benefits and limitations of these technologies are discussed, along with areas for further research and development. Overall, this Review underscores the importance of CCUS.