Comparing cardiovascular adverse events in cancer patients: A meta-analysis of combination therapy with angiogenesis inhibitors and immune checkpoint inhibitors versus angiogenesis inhibitors alone

被引：20

作者：

Crocetto, Felice ^{[1
,17
]}

Ferro, Matteo ^{[2
]}

Buonerba, Carlo ^{[3
,4
]}

Bardi, Luca ^{[5
]}

Dolce, Pasquale ^{[6
]}

Scafuri, Luca ^{[3
,4
]}

Mirto, Benito Fabio ^{[1
]}

Verde, Antonio ^{[3
,4
]}

Sciarra, Antonella ^{[7
]}

Barone, Biagio ^{[1
]}

Calogero, Armando ^{[8
]}

Sagnelli, Caterina ^{[9
]}

Busetto, Gian Maria ^{[10
]}

Del Giudice, Francesco ^{[11
]}

Cilio, Simone ^{[1
]}

Sonpavde, Guru ^{[12
]}

Di Trolio, Rossella ^{[13
]}

Della Ratta, Giuseppe Luca ^{[14
,16
]}

Barbato, Gabriele ^{[15
]}

Di Lorenzo, Giuseppe

机构：

[1] Univ Naples Federico II, Dept Neurosci Reprod Sci & Odontostomatol, Naples, Italy

[2] European Inst Oncol IEO, Div Urol, IRCCS, Milan, Italy

[3] Assoc ORA Oncol Res Assistance, I-80049 Somma Vesuviana, Italy

[4] ASL Salerno, Andrea Tortora Hosp, Oncol Unit, I-84016 Pagani, Italy

[5] Univ Naples Federico II, Dept Adv Biomed Sci, Div Cardiol, Naples, Italy

[6] Federico II Univ Naples, Dept Publ Hlth, Naples, Italy

[7] Univ Campania Luigi Vanvitelli, Dept Translat Med Sci, Naples, Italy

[8] Univ Naples Federico II, Dept Adv Biomed Sci, I-80131 Naples, Italy

[9] Univ Campania Luigi Vanvitelli, Dept Mental Hlth & Publ Med, Sect Infect Dis, I-80138 Naples, Italy

[10] Univ Foggia, Dept Urol & Renal Transplantat, Foggia, Italy

[11] Sapienza Univ, Dept Maternal Infant & Urol Sci, Rome, Italy

[12] Advent Hlth Canc Inst, Div Med Oncol, Orlando, FL USA

[13] Ist Nazl Tumori IRCCS Fdn G Pascale, Melanoma Canc Immunotherapy & Innovat Therapy, Naples, Italy

[14] Human Gavazzeni, Oncol Unit, Bergamo, Italy

[15] Anastasia Guerriero Hosp, Dept Anesthesia & Intens Care, Caserta Local Hlth Author, Marcianise, Caserta, Italy

[16] Univ Molise, Dept Med & Hlth Sci Vincenzo Tiberio, I-86100 Campobasso, Italy

[17] Univ Federico II, Dept Neurosci & Reprod & Odontostomatol Sci, Via Sergio Pansini 5, I-80131 Naples, Italy

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2023年 / 188卷

关键词：

Immune checkpoint inhibitors; Angiogenesis inhibitors; Cardiovascular toxicity; VENOUS THROMBOEMBOLIC EVENTS; TYROSINE KINASE INHIBITORS; HEPATOCELLULAR-CARCINOMA; VEGFR-TKIS; OPEN-LABEL; RISK; PLUS;

D O I：

10.1016/j.critrevonc.2023.104059

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Anti-VEGF (vascular endothelial growth factor) agents were associated with increased risk of several cardiovascular events, while one meta-analysis did not show any significantly increased risk of cardiotoxicity associated with the use of immune checkpoint inhibitors (ICIs). This meta-analysis of randomized-controlled trials (RCTs) was designed to compare cardiovascular toxicity of anti-VEGF agents plus ICI vs anti-VEGF agents without ICIs. A systematic search of the literature was conducted to include all full papers reporting about phase II and III randomized controlled trials (RCTs) conducted in patients with solid malignancies randomized to an anti-VEGF agent plus an ICI vs. an anti-VEGF agent without an ICI. Overall incidences of cardiovascular events were compared between these two treatment groups estimating the corresponding odds ratios. This analysis suggests that ICIs may increase the risk of cardiovascular toxicities associated with anti-VEGF therapies. Further research, including real world studies, is warranted.

引用

页数：10

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