Salivary biomarkers as potential diagnostic tool for temporomandibular disorders: A comprehensive review

被引：1
作者：
Aoun, Yasmina [1 ]
Ejbeh, Rita [1 ]
Youssef, Abboud [2 ]
Hobeiche, Joseph [2 ]
机构：
[1] St Joseph Univ Beirut, Fac Dent Med, Dept Orthodont & Dentofacial Orthoped, Beirut, Lebanon
[2] St joseph Univ Beirut, Fac Dent Med, Dept fixed prosthodont & occlus, Damascus Rd, Beirut, Lebanon
来源：
CRANIO-THE JOURNAL OF CRANIOMANDIBULAR & SLEEP PRACTICE | 2023年
关键词：
Temporomandibular joint; temporomandibular disorders; diagnosis; biomarkers; saliva; NERVE GROWTH-FACTOR; RHEUMATOID-ARTHRITIS; OXIDATIVE STRESS; SYNOVIAL-FLUID; OROFACIAL PAIN; CORTISOL; METALLOPROTEINASES; NEUROPEPTIDES; ASSOCIATION; DESTRUCTION;
D O I：
10.1080/08869634.2023.2229607
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
ObjectiveTo review the current scientific literature concerning the implication of biomarkers collected from saliva in the diagnosis of temporomandibular disorders (TMD).MethodsA comprehensive literature search was conducted on PubMed, Google Scholar, Embase, MEDLINE and Web of Science to gather articles published between 2012 and 2021. Based on the eligibility criteria, articles were reviewed in full and precise data was extracted.ResultsNine clinical studies were selected. Participants with TMD were all diagnosed according to the Diagnostic Criteria for Temporomandibular Disorders. Specific biomarkers were examined from saliva samples. Results related to TMD showed a significant range of variability.ConclusionSpecific salivary biomarkers have been investigated, but current efforts are aiming to search for more possible biomarkers from saliva samples as a safe procedure. Future research needs to consider the sensitivity and specificity of these biomarkers as diagnostic tools for TMD.
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页数：10
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