Relay Organophotoredox/N-Heterocyclic Carbene Catalysis-Enabled Asymmetric Synthesis of Dibenzoxazepine-Fused Pyrrolidinones

被引：6
作者：
Hussain, Yaseen [1 ]
Sharma, Deepak [1 ]
Tamanna [1 ]
Chauhan, Pankaj [1 ]
机构：
[1] Indian Inst Technol Jammu, Dept Chem, Jagti 181221, Jammu & Kashmir, India
来源：
ORGANIC LETTERS | 2023年 / 25卷 / 14期
关键词：
PHOTOREDOX CATALYSIS; COOPERATIVE PHOTOREDOX; TERTIARY-AMINES; DUAL CATALYSIS; ALDEHYDES; UMPOLUNG; KETONES; ACID;
D O I：
10.1021/acs.orglett.3c00685
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An unprecedented highly stereoselective synthesis of pyrrolo[1,2-d][1,4]oxazepin-3(2H)-ones has been accomplished via photoredox/N-heterocyclic carbene (NHC) relay catalysis. A wide range of substituted dibenzoxazepines and aryl/hetereoaryl enals were well accommodated under the organic photoredox catalysis- promoted amine oxidation to generate the imines, followed by a NHC-catalyzed [3 + 2] annulation reaction to achieve excellent diastereo- and enantioselectivities of the dibenzoxazepine-fused pyrrolidinones.
引用
收藏
页码：2520 / 2524
页数：5
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