Influence of sex in alcohol-related liver disease: Pre-clinical and clinical settings

被引：26

作者：

Bizzaro, Debora ^{[1
]}

Becchetti, Chiara ^{[2
]}

Trapani, Silvia ^{[3
]}

Lavezzo, Bruna ^{[4
]}

Zanetto, Alberto ^{[1
]}

D'Arcangelo, Francesca ^{[1
]}

Merli, Manuela ^{[5
]}

Lapenna, Lucia ^{[5
]}

Invernizzi, Federica ^{[6
]}

Taliani, Gloria ^{[7
]}

Burra, Patrizia ^{[1
]}

机构：

[1] Padua Univ Hosp, Dept Surg Oncol & Gastroenterol, Gastroenterol & Multivisceral Transplant Unit, Padua, Italy

[2] ASST Grande Osped Metropolitano Niguarda, Hepatol & Gastroenterol, Milan, Italy

[3] Natl Inst Hlth, Italian Natl Transplant Ctr, Rome, Italy

[4] AOU Citta Salute & Sci, Liver Transplant Ctr, Anesthesia & Intens Care Unit 2, Turin, Italy

[5] Sapienza Univ Rome, Ctr Diag & Treatment Portal Hypertens, Dept Translat & Precis Med, Rome, Italy

[6] IRCCS Osped San Raffaele, Ctr Liver Dis, Div Internal Med & Hepatol, Milan, Italy

[7] Sapienza Univ Rome, Policlin Umberto Hosp 1, Dept Publ Hlth & Infect Dis, Infect & Trop Med Unit, Rome, Italy

来源：

UNITED EUROPEAN GASTROENTEROLOGY JOURNAL | 2023年 / 11卷 / 02期

关键词：

alcohol; cirrhosis; gender; portal hypertension; sex; HIGH-DOSE NALTREXONE; GENDER-DIFFERENCES; TRANSPLANTATION; HEPATITIS; DEPENDENCE; ABUSE; RISK; PHARMACOKINETICS; CONSUMPTION; PREDICTORS;

D O I：

10.1002/ueg2.12370

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Alcohol-related liver disease (ArLD) is a major cause of chronic liver disease globally. Traditionally, ArLD was mostly a concern in men rather than in women; however, such a sex gap is rapidly narrowing due to increasing chronic alcohol consumption among women. Female sex is more vulnerable to the harmful effects of alcohol with a higher risk of progression to cirrhosis and development of associated complications. The relative risk of cirrhosis and liver-related mortality is significantly higher in women than in men. Our review endeavors to summarize the current knowledge on sex differences in alcohol metabolism, pathogenesis of ArLD, disease progression, indication for liver transplant and pharmacological treatments of ArLD, and provide evidence in support of a sex-specific management of these patients.

引用

页码：218 / 227

页数：10

共 60 条

[1] Combined pharmacotherapies and behavioral interventions for alcohol dependence - The COMBINE study: A randomized controlled trial [J].

Anton, RF ;

O'Malley, SS ;

Ciraulo, DA ;

Cisler, RA ;

Couper, D ;

Donovan, DM ;

Gastfriend, DR ;

Hosking, JD ;

Johnson, BA ;

LoCastro, JS ;

Longabaugh, R ;

Mason, BJ ;

Mattson, ME ;

Miller, WR ;

Pettinati, HM ;

Randall, CL ;

Swift, R ;

Weiss, RD ;

Williams, LD ;

Zweben, A .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2006, 295 (17) :2003-2017

[2]

AVOGARO A, 1987, DIABETES RES CLIN EX, V5, P23

[3] Gender differences in pharmacokinetics of alcohol [J].

Baraona, E ;

Abittan, CS ;

Dohmen, K ;

Moretti, M ;

Pozzato, G ;

Chayes, ZW ;

Schaefer, C ;

Lieber, CS .

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2001, 25 (04) :502-507

[4] Naltrexone and cognitive behavioral therapy for the treatment of alcohol dependence: Do sex differences exist? [J].

Baros, A. M. ;

Latham, P. K. ;

Anton, R. F. .

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2008, 32 (05) :771-776

[5] Moderate alcohol consumption is associated with significant fibrosis progression in NAFLD [J].

Blomdahl, Julia ;

Nasr, Patrik ;

Ekstedt, Mattias ;

Kechagias, Stergios .

HEPATOLOGY COMMUNICATIONS, 2023, 7 (01)

[6] Population-level risks of alcohol consumption by amount, geography, age, sex, and year: a systematic analysis for the Global Burden of Disease Study 2020 [J].

Bryazka, Dana ;

Reitsma, Marissa B. ;

Griswold, Max G. ;

Abate, Kalkidan Hassen ;

Abbafati, Cristiana ;

Kangevari, Mohsen Abbasi ;

Kangevari, Zeinab Abbasi ;

Abdoli, Amir ;

Abdollahi, Mohammad ;

Abdullah, Abu Yousuf Md ;

Abhilash, E. S. ;

Abu Gharbieh, Eman ;

Acuna, Juan Manuel ;

Addolorato, Giovanni ;

Adebayo, Oladimeji M. ;

Adekanmbi, Victor ;

Adhikari, Kishor ;

Adhikari, Sangeet ;

Adnani, Qorinah Estiningtyas Sakilah ;

Afzal, Saira ;

Agegnehu, Wubetu Yimam ;

Aggarwal, Manik ;

Ahinkorah, Bright Opoku ;

Ahmad, Araz Ramazan ;

Ahmad, Sajjad ;

Ahmad, Tauseef ;

Ahmadi, Ali ;

Ahmadi, Sepideh ;

Ahmed, Haroon ;

Rashid, Tarik Ahmed ;

Akunna, Chisom Joyqueenet ;

Al Hamad, Hanadi ;

Alam, Md Zakiul ;

Alem, Dejene Tsegaye ;

Alene, Kefyalew Addis ;

Alimohamadi, Yousef ;

Alizadeh, Atiyeh ;

Allel, Kasim ;

Alonso, Jordi ;

Alvand, Saba ;

Guzman, Nelson Alvis ;

Amare, Firehiwot ;

Ameyaw, Edward Kwabena ;

Amiri, Sohrab ;

Ancuceanu, Robert ;

Anderson, Jason A. ;

Andrei, Catalina Liliana ;

Andrei, Tudorel ;

Arabloo, Jalal ;

Arshad, Muhammad .

LANCET, 2022, 400 (10347) :185-235

[7] Does liver-disease aetiology have a role in cerebral blood-flow alterations in liver cirrhosis? [J].

Burra, P ;

Senzolo, M ;

Pizzolato, G ;

Ermani, M ;

Chierichetti, F ;

Bassanello, M ;

Naccarato, R ;

Dam, M .

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2004, 16 (09) :885-890

[8] Liver Transplantation for Alcoholic Liver Disease in Europe: A Study from the ELTR (European Liver Transplant Registry) [J].

Burra, P. ;

Senzolo, M. ;

Adam, R. ;

Delvart, V. ;

Karam, V. ;

Germani, G. ;

Neuberger, J. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2010, 10 (01) :138-148

[9] Histological features after liver transplantation in alcoholic cirrhotics [J].

Burra, P ;

Mioni, D ;

Cecchetto, A ;

Cillo, U ;

Zanus, G ;

Fagiuoli, S ;

Naccarato, R ;

Martines, D .

JOURNAL OF HEPATOLOGY, 2001, 34 (05) :716-722

[10] Limitations of current liver donor allocation systems and the impact of newer indications for liver transplantation [J].

Burra, Patrizia ;

Samuel, Didier ;

Sundaram, Vinay ;

Duvoux, Christophe ;

Petrowsky, Henrik ;

Terrault, Norah ;

Jalan, Rajiv .

JOURNAL OF HEPATOLOGY, 2021, 75 :S178-S190

← 1 2 3 4 5 6 →