A comparison of computed tomography imaging with histopathology in the sensitivity and correlation of evaluating coronary arterial calcification

被引:0
|
作者
Liu, Yun-Fei [1 ,2 ]
Ma, Yan-He [3 ]
Wang, Chang-Yue [4 ]
Zhang, Xiang-Li [1 ,2 ,6 ]
Liang, Ke-Ke [1 ,2 ]
Tao, Jing [5 ]
Guo, Lin [1 ,7 ]
Gao, Bu-Lang [1 ]
机构
[1] Zhengzhou Seventh Peoples Hosp, Dept Crit Care Med, Zhengzhou, Peoples R China
[2] Zhengzhou Univ, Dept Heart Transplantat Ctr, Affiliated Hosp 1, Zhengzhou, Peoples R China
[3] Tianjin Chest Hosp, Dept Radiol, Tianjin, Peoples R China
[4] Tianjin Med Univ, Dept Anat & Histoembryol, Tianjin, Peoples R China
[5] Henan Prov Childrens Hosp, Pathol Dept, Zhengzhou, Peoples R China
[6] Zhengzhou Univ, Dept Heart Transplantat Ctr, Affiliated Hosp 1, 1 Jian She East Rd, Zhengzhou 450052, Peoples R China
[7] Zhengzhou Seventh Peoples Hosp, Dept Crit Care Med, 17 Jingnan Fifth Rd,Zhengzhou Econ & Technol Dev Z, Zhengzhou 450016, Peoples R China
关键词
Coronary artery calcification; computed tomography; stenosis; histopathology; ATHEROSCLEROTIC PLAQUE; DUAL-SOURCE; SPOTTY CALCIFICATION; DISEASE EVENTS; SOURCE CT; CALCIUM; PROGRESSION; QUANTIFICATION; STENOSIS; INSIGHTS;
D O I
10.21037/qims-22-603
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Background: The sensitivity and correlation of coronary computed tomography angiography (CTA) as compared with histopathology are unknown in evaluating coronary arterial calcification. In this study, we retrospectively evaluated qualitatively and quantitatively the sensitivity and correlation of coronary CTA compared with histopathology in assessing coronary arterial calcification.Methods: This study was conducted on 12 randomly selected cadavers aged over 40 years at the time of death, and 53 segments of coronary arteries from these 12 cadavers were obtained from the Human Anatomy Laboratory of Tianjin Medical University. The artery segments were scanned using contrasted-enhanced dual-source computed tomography (DSCT) with an axial slice thickness of 0.6 mm. Coronary artery calcification in a coronary segment was defined as the presence of 1 or more voxels with a CT density > 130 Hounsfield units. According to the arc of calcification in the cross section of the coronary artery wall, calcified plaques were divided into three categories: mild, moderate, and severe calcification. The coronary artery stenosis caused by calcified plaque was observed and calculated with multiplanar reconstruction (MPR), maximum density projection, volume rendering (VR), and cross-sectional reconstruction. After CT enhancement scanning, the coronary artery specimens were cut into 4-mm long segments and embedded in paraffin for pathological staining. Pathological classification and coronary artery stenosis measured with pathological analysis were used as comparison criteria.Results: Histopathology detected 69 Vb-type plaques, while DSCT detected 57 calcified plaques. The sensitivity of CT for detecting mild, moderate, and severe calcified plaques were 88.3% [95% confidence interval (CI): 74.1-95.6%], 100% (95% CI: 69.8-100%), and 100% (95% CI: 73.2-100%), respectively. DSCT had a significant (P < 0.001) correlation with histopathology in quantifying coronary artery stenosis caused by mild, moderate, and severe calcified plaques (r=0.97, r=0.92, and r=0.79, respectively). Compared with histopathology, DSCT overestimated coronary artery stenosis caused by mild, moderate, and severe calcified plaques (3.2%+/- 2.0%, 4.9%+/- 4.7%, and 14.7%+/- 8.2%, respectively; P < 0.05).Conclusions: DSCT contrast enhancement scanning can detect and characterize coronary artery calcification with a good correlation with histopathologic quantification of coronary artery stenosis caused by different types of calcified plaques, even though coronary CTA may overestimate the stenosis.
引用
收藏
页码:2426 / 2440
页数:15
相关论文
共 50 条
  • [41] A calcification subtraction method for postmortem coronary computed tomography angiography
    Inokuchi, Go
    Kojima, Masatoshi
    Chiba, Fumiko
    Hoshioka, Yumi
    Yoshida, Maiko
    Tsuneya, Shigeki
    Iwase, Hirotaro
    INTERNATIONAL JOURNAL OF LEGAL MEDICINE, 2025, 139 (01) : 119 - 130
  • [42] Refining Coronary Heart Disease Event Prediction in Young and Old Individuals by Coronary Artery Calcification Imaging With Computed Tomography
    Gerber, Thomas C.
    Kantor, Birgit
    MAYO CLINIC PROCEEDINGS, 2014, 89 (10) : 1324 - 1327
  • [43] Patterns of Coronary Calcification and Their Impact on the Diagnostic Accuracy of Computed Tomography Coronary Angiography
    Noll, Dariusz
    Kruk, Mariusz
    Demkow, Marcin
    Pregowski, Jerzy
    Kaczmarska, Edyta
    Kryczka, Karolina
    Pracon, Radoslaw
    Dzielinska, Zofia
    Sleszycka, Justyna
    Witkowski, Adam
    Ruzyllo, Witold
    Kepka, Cezary
    JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 2018, 42 (02) : 263 - 268
  • [44] Coronary arterial calcification: A review of mechanisms, promoters and imaging
    Andrews, Jordan
    Psaltis, Peter J.
    Di Bartolo, Belinda A.
    Nicholls, Stephen J.
    Puri, Rishi
    TRENDS IN CARDIOVASCULAR MEDICINE, 2018, 28 (08) : 491 - 501
  • [45] Distribution of calcification in carotid endarterectomy tissues: Comparison of micro-computed tomography imaging with histology
    Ababneh, Bashar
    Rejjal, Loui
    Pokharel, Yashashwi
    Nambi, Vijay
    Wang, Xukui
    Tung, Ching-Hsuan
    Han, Richard I.
    Taylor, Addison A.
    Kougias, Panagiotis
    Lumsden, Alan B.
    Lawrie, Gerald
    Reardon, Michael
    Ballantyne, Christie M.
    Morrisett, Joel D.
    Brunner, Gerd
    VASCULAR MEDICINE, 2014, 19 (05) : 343 - 350
  • [46] Dual source computed tomography for the assessment of coronary artery calcification. A comparison with the current standard method: electron-beam computed tomography
    Reinsch, N.
    Sievers, B.
    Hoefs, C.
    Moehlenkamp, S.
    Budde, T.
    Seibel, R.
    Erbel, R.
    EUROPEAN HEART JOURNAL, 2008, 29 : 621 - 622
  • [47] Comparison of Coronary Computed Tomography Angiography With Standard of Care for Evaluating Acute Chest Pain
    Gottlieb, Michael
    Sompalli, Vinootna
    Parker, C. Woodworth
    ANNALS OF EMERGENCY MEDICINE, 2024, 83 (04) : 398 - 400
  • [48] Coronary artery imaging by multislice, spiral computed tomography: Comparison with angiographic results
    Inoue, F
    Sato, Y
    Imazeki, T
    Furuhashi, S
    Takahashi, M
    Kanmatsuse, K
    RADIOLOGY, 2002, 225 : 481 - 481
  • [49] Correlation and assessment of coronary artery luminal stenosis: Post-mortem computed tomography angiogram versus histopathology
    Singh, Mansharan Kaur Chainchel
    Rashid, Saiful Nizam Abdul
    Hamid, Suzana Abdul
    Mahmood, Mohd Shah
    Feng, Siew Sheue
    Nawawi, Hapizah Mohd
    Omar, Effat
    FORENSIC SCIENCE INTERNATIONAL, 2020, 308
  • [50] Assessment of vascular calcification with computed tomography and simple imaging tools
    Seyahi, Nurhan
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 2007, 22 (03) : 961 - 961