The Role of Histone Acetylation Modification in Dental Tissue-Derived Mesenchymal Stem Cells and Odontogenesis

被引：4

作者：

Chen, Haoling ^{[1
]}

Huang, Zijing ^{[2
]}

Chen, Chuxiao ^{[3
]}

机构：

[1] Southern Med Univ, Stomatol Hosp, Dept Pediat Dent, Guangzhou, Peoples R China

[2] Southern Med Univ, Stomatol Hosp, Dept Endodont, Guangzhou, Peoples R China

[3] Sun Yat Sen Univ, Affiliated Hosp 1, Organ Transplant Ctr, Guangzhou, Peoples R China

来源：

CELLULAR REPROGRAMMING | 2023年 / 25卷 / 01期

关键词：

dental tissue-derived MSCs; odontogenesis; histone acetylation; histone deacetylation; HATs; HDACs; OSTEOGENIC DIFFERENTIATION; DEACETYLASE INHIBITORS; SIRTUIN; 6; OSTEOBLASTIC DIFFERENTIATION; PROLIFERATION; ACETYLTRANSFERASE; EXPRESSION; METHYLTRANSFERASES; METABOLISM; REGULATORS;

D O I：

10.1089/cell.2022.0091

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Odontogenesis is a complex physiological process that is based on dental tissue-derived mesenchymal stem cells (MSCs). Dental tissue-derived MSCs are the stem cell populations isolated and characterized from different parts of the oral cavity, and are considered as promising candidates for stem cell-based therapy. During odontogenesis, epigenetic factors can influence the proliferation, differentiation, or apoptosis of dental tissue-derived MSCs. As one of the epigenetic modifications, histone acetylation modification is critical for the proper regulation of many biological processes, including transcriptional regulation of cell cycle progression and cell fate. In odontogenesis, histone acetylation and deacetylation play crucial roles in odontogenic differentiation of dental tissue-derived MSCs. In this review, we aim to outline the general features of acetylation modification and describe their roles in odontogenic differentiation of dental tissue-derived MSCs, as well as their future implications in the field of novel regenerative therapies for the dentine-pulp complex.

引用

页码：11 / 19

页数：9

共 68 条

[51] Sirt6 regulates postnatal growth plate differentiation and proliferation via Ihh signaling [J].

Piao, Jinying ;

Tsuji, Kunikazu ;

Ochi, Hiroki ;

Iwata, Munetaka ;

Koga, Daisuke ;

Okawa, Atsushi ;

Morita, Sadao ;

Takeda, Shu ;

Asou, Yoshinori .

SCIENTIFIC REPORTS, 2013, 3

[52] Stem Cells from Dental Pulp: What Epigenetics Can Do with Your Tooth [J].

Rodas-Junco, Beatriz A. ;

Canul-Chan, Michel ;

Rojas-Herrera, Rafael A. ;

De-la-Pena, Clelia ;

Nic-Can, Geovanny I. .

FRONTIERS IN PHYSIOLOGY, 2017, 8

[53] Histone acetyltransferases [J].

Roth, SY ;

Denu, JM ;

Allis, CD .

ANNUAL REVIEW OF BIOCHEMISTRY, 2001, 70 :81-120

[54]

Sedgley Christine M, 2012, Dent Clin North Am, V56, P549, DOI 10.1016/j.cden.2012.05.004

[55]

Seo Ji-Yun, 2015, Restor Dent Endod, V40, P14

[56] The Regulatory Role of Histone Deacetylase Inhibitors in Fgf4 Expression Is Dependent on the Differentiation State of Pluripotent Stem Cells [J].

Shi, Guilai ;

Gao, Furong ;

Jin, Ying .

JOURNAL OF CELLULAR PHYSIOLOGY, 2011, 226 (12) :3190-3196

[57] The language of covalent histone modifications [J].

Strahl, BD ;

Allis, CD .

NATURE, 2000, 403 (6765) :41-45

[58] The Effect of SIRT6 on the Odontoblastic Potential of Human Dental Pulp Cells [J].

Sun, Hua Ling ;

Wu, Yan Ru ;

Huang, Cui ;

Wang, Jia Wei ;

Fu, Dong Jie ;

Liu, Yin Chen .

JOURNAL OF ENDODONTICS, 2014, 40 (03) :393-398

[59] Histone core modifications regulating nucleosome structure and dynamics [J].

Tessarz, Peter ;

Kouzarides, Tony .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2014, 15 (11) :703-708

[60] Genetic an environmental influences on human dental variation: A critical evaluation of studies involving twins [J].

Townsend, Grant ;

Hughes, Toby ;

Luciano, Michelle ;

Bockmann, Michelle ;

Brook, Alan .

ARCHIVES OF ORAL BIOLOGY, 2009, 54 :S45-S51

← 1 2 3 4 5 6 7 →