The Role of Histone Acetylation Modification in Dental Tissue-Derived Mesenchymal Stem Cells and Odontogenesis

被引:4
作者
Chen, Haoling [1 ]
Huang, Zijing [2 ]
Chen, Chuxiao [3 ]
机构
[1] Southern Med Univ, Stomatol Hosp, Dept Pediat Dent, Guangzhou, Peoples R China
[2] Southern Med Univ, Stomatol Hosp, Dept Endodont, Guangzhou, Peoples R China
[3] Sun Yat Sen Univ, Affiliated Hosp 1, Organ Transplant Ctr, Guangzhou, Peoples R China
关键词
dental tissue-derived MSCs; odontogenesis; histone acetylation; histone deacetylation; HATs; HDACs; OSTEOGENIC DIFFERENTIATION; DEACETYLASE INHIBITORS; SIRTUIN; 6; OSTEOBLASTIC DIFFERENTIATION; PROLIFERATION; ACETYLTRANSFERASE; EXPRESSION; METHYLTRANSFERASES; METABOLISM; REGULATORS;
D O I
10.1089/cell.2022.0091
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Odontogenesis is a complex physiological process that is based on dental tissue-derived mesenchymal stem cells (MSCs). Dental tissue-derived MSCs are the stem cell populations isolated and characterized from different parts of the oral cavity, and are considered as promising candidates for stem cell-based therapy. During odontogenesis, epigenetic factors can influence the proliferation, differentiation, or apoptosis of dental tissue-derived MSCs. As one of the epigenetic modifications, histone acetylation modification is critical for the proper regulation of many biological processes, including transcriptional regulation of cell cycle progression and cell fate. In odontogenesis, histone acetylation and deacetylation play crucial roles in odontogenic differentiation of dental tissue-derived MSCs. In this review, we aim to outline the general features of acetylation modification and describe their roles in odontogenic differentiation of dental tissue-derived MSCs, as well as their future implications in the field of novel regenerative therapies for the dentine-pulp complex.
引用
收藏
页码:11 / 19
页数:9
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