Position paper of the Polish Expert Group on the use of pitavastatin in the treatment of lipid disorders in Poland endorsed by the Polish Lipid Association

被引:8
作者
Banach, Maciej [1 ,2 ,3 ,4 ]
Surma, Stanislaw [5 ]
Kaplon-Cieslicka, Agnieszka [6 ,7 ]
Mitkowski, Przemyslaw [8 ]
Dzida, Grzegorz [9 ]
Tomasik, Tomasz [10 ]
Mastalerz-Migas, Agnieszka [11 ]
机构
[1] Med Univ Lodz MUL, Dept Prevent Cardiol & Lipidol, 281-289 Rzgowska St, PL-93338 Lodz, Poland
[2] Johns Hopkins Univ, Ciccarone Ctr Prevent Cardiovasc Dis, Dept Med, Div Cardiol,Sch Med, Baltimore, MD USA
[3] Univ Zielona Gora, Cardiovasc Res Ctr, Zielona Gora, Poland
[4] Polish Mothers Mem Hosp Res Inst PMMHRI, Dept Cardiol & Adult Congenital Heart Dis, Lodz, Poland
[5] Med Univ Silesia, Dept Internal Med & Clin Pharmacol, Katowice, Poland
[6] Med Univ Warsaw, Chair 1, Warsaw, Poland
[7] Med Univ Warsaw, Dept Cardiol, Warsaw, Poland
[8] Karol Marcinkowski Poznan Med Univ, Dept Cardiol 1, Poznan, Poland
[9] Med Univ Lublin, Dept Internal Med, Lublin, Poland
[10] Jagiellonian Univ, Dept Family Med, Coll Med, Krakow, Poland
[11] Piastow Slaski Med Univ, Dept Family Med, Wroclaw, Poland
关键词
lipid disorders; lipid lowering therapy; therapy personalisation; pitavastatin; statin intolerance; DENSITY-LIPOPROTEIN CHOLESTEROL; ACUTE MYOCARDIAL-INFARCTION; INTENSIVE STATIN THERAPY; DRUG-DRUG INTERACTIONS; CARDIOVASCULAR-DISEASE; GLOBAL BURDEN; LDL-CHOLESTEROL; LOWERING THERAPY; CLINICAL-TRIALS; RISK-FACTORS;
D O I
10.5114/aoms/175879
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Lipid disorders, primarily hypercholesterolemia, are the most common cardiovascular (CV) risk factor in Poland (this applies even 3/4 of people). The low -density lipoprotein cholesterol (LDL-C) serum level is the basic lipid parameter that should be measured to determine CV risk and determines the aim and target of lipid -lowering treatment (LLT). Lipid -lowering treatment improves cardiovascular prognosis and prolongs life in both primary and secondary cardiovascular prevention. Despite the availability of effective lipid -lowering drugs and solid data on their beneficial effects, the level of LDL-C control is highly insufficient. This is related, among other things, to physician inertia and patients' fear of side effects. The development of lipidology has made drugs available with a good safety profile and enabling personalisation of therapy. Pitavastatin, the third most potent lipid -lowering statin, is characterised by a lower risk of muscle complications and new cases of diabetes due to its being metabolised differently. Thus, pitavastatin is a very good therapeutic option in patients at high risk of diabetes or with existing diabetes, and in patients at cardiovascular risk. This expert opinion paper attempts at recommendation on the place and possibility of using pitavastatin in the treatment of lipid disorders.
引用
收藏
页码:28 / 42
页数:15
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