CIRCULAR RNAS: NOVEL ACTORS OF WNT SIGNALING PATHWAY IN LUNG CANCER PROGRESSION

被引：33

作者：

Alimohammadi, Mina ^{[1
]}

Gholinezhad, Yasaman ^{[2
]}

Mousavi, Vahide ^{[3
]}

Kahkesh, Samaneh ^{[4
]}

Rezaee, Malihe ^{[2
]}

Yaghoobi, Alireza ^{[2
]}

Mafi, Alireza ^{[5
,6
]}

Araghi, Mahmood ^{[7
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Sch Med, Dept Immunol, Tehran, Iran

[2] Shahid Beheshti Univ Med Sci, Sch Med, Dept Pharmacol, Tehran, Iran

[3] Bushehr Univ Med Sci, Sch Med, Bushehr, Iran

[4] Shahid Chamran Univ Ahvaz, Fac Sci, Ahvaz, Iran

[5] Isfahan Univ Med Sci, Sch Pharm & Pharmaceut Sci, Dept Clin Biochem, Esfahan, Iran

[6] Isfahan Univ Med Sci, Nutr & Food Secur Res Ctr, Esfahan, Iran

[7] Zanjan Univ Med Sci, Sch Med, Dept Pathol, Zanjan, Iran

来源：

EXCLI JOURNAL | 2023年 / 22卷

关键词：

CircRNA; Wnt; lung cancer; signaling cascades; mechanism; SPLICING FACTOR NOVA2; CELLS PROLIFERATION; DOWN-REGULATION; POOR-PROGNOSIS; UP-REGULATION; EXPRESSION; CATENIN; GROWTH; METASTASIS; MIGRATION;

D O I：

10.17179/excli2023-6209

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Circular RNAs (CircRNAs) are a class of regulatory RNA transcripts, which are ubiquitously expressed in eukar-yotes. CircRNA dysregulation has been shown to disrupt the interaction of the Wnt/f3-catenin pathway, which regulates several biological processes involved in tumorigenesis, thereby contributing to the development and progression of cancer. Interactions of tumor-derived circRNAs with the Wnt/f3-catenin signaling pathway provide both clinical diagnostic biomarkers and promising therapeutic targets. In this review, we outlined current evidence on the roles of circRNAs associated with the Wnt/f3-catenin pathway in regulating lung cancer formation and development. We believe that our findings will assist in the advancement or establishment of circRNA-based lung cancer therapeutic approaches.

引用

页码：645 / 669

页数：25

共 149 条

[41] Wise, a context-dependent activator and inhibitor of Wnt signalling [J].