Fe(III)-Catalyzed Aerobic Oxidation of 1,4-Diols

被引：6

作者：

Li, Junlin ^{[1
]}

Liu, Jinxian ^{[1
]}

Fu, Chunling ^{[1
]}

Ma, Shengming ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Lab Mol Recognit & Synth, Hangzhou 310027, Zhejiang, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2023年 / 41卷 / 16期

基金：

中国国家自然科学基金;

关键词：

Aerobic oxidation; 1,4-Diol; gamma-Lactone; Catalysis; Iron; TEMPO; KCl; Chemoselectivity; Chirality; Selective oxidation; ALCOHOLS; LACTONE; LACTONIZATION; CATALYSIS; DIOLS;

D O I：

10.1002/cjoc.202200768

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Aerobic oxidation has been catching more and more attention because of its atom economy and environmental friendliness. Oxidation of diols is a challenge due to various oxidative products. Thus, highly selective aerobic oxidation affording specific products is of current interest. In this work, a combination of Fe(NO3)(3)center dot 9H(2)O/TEMPO/KCl catalysis has been identified as an efficient recipe for the aerobic oxidation of 1,4-diols affording gamma-butyrolactones under mild conditions. The reaction exhibits decent chemo- and regioselectivity of symmetrical and unsymmetrical 1,4-diols. The optically active gamma-lactones may also be prepared from optically active 1,4-diols without erosion of the ee via this method. Furthermore, this approach was successfully applied to synthesize NBP, a commercial drug.

引用

页码：1963 / 1966

页数：4

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