The impact of loneliness and social isolation on the development of cognitive decline and Alzheimer's Disease

被引：60
作者：
Ren, Yi [3 ,4 ,5 ]
Savadlou, Aisouda [1 ,5 ,6 ]
Park, Soobin [1 ,5 ,6 ]
Siska, Paul [1 ,5 ,6 ]
Epp, Jonathan R. [3 ,4 ,5 ]
Sargin, Derya [1 ,2 ,5 ,6 ,7 ]
机构：
[1] Univ Calgary, Dept Psychol, Calgary, AB, Canada
[2] Univ Calgary, Dept Physiol & Pharmacol, Calgary, AB, Canada
[3] Univ Calgary, Dept Cell Biol & Anat, Calgary, AB, Canada
[4] Univ Calgary, Cumming Sch Med, Calgary, AB, Canada
[5] Univ Calgary, Hotchkiss Brain Inst, Calgary, AB, Canada
[6] Univ Calgary, Alberta Childrens Hosp Res Inst, Calgary, AB, Canada
[7] Univ Calgary, 2500 Univ Ave Dr NW, Calgary, AB T2N 1N4, Canada
来源：
FRONTIERS IN NEUROENDOCRINOLOGY | 2023年 / 69卷
基金：
加拿大自然科学与工程研究理事会;
关键词：
Alzheimer?s Disease; Loneliness; Social isolation; Risk factors; Cognition; Sex differences; PITUITARY-ADRENOCORTICAL AXIS; GLYCOGEN-SYNTHASE KINASE-3; ISOLATION-TRIGGERED ONSET; TIME PHYSICAL-ACTIVITY; ISOLATION REARED RATS; CDK5 ACTIVATOR P35; LEISURE ACTIVITIES; RISK-FACTORS; OLDER MEN; LATE-LIFE;
D O I：
10.1016/j.yfrne.2023.101061
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Alzheimer's Disease (AD) is the leading cause of dementia, observed at a higher incidence in women compared with men. Treatments aimed at improving pathology in AD remain ineffective to stop disease progression. This makes the detection of the early intervention strategies to reduce future disease risk extremely important. Isolation and loneliness have been identified among the major risk factors for AD. The increasing prevalence of both loneliness and AD emphasizes the urgent need to understand this association to inform treatment. Here we present a comprehensive review of both clinical and preclinical studies that investigated loneliness and social isolation as risk factors for AD. We discuss that understanding the mechanisms of how loneliness exacerbates cognitive impairment and AD with a focus on sex differences will shed the light for the underlying mechanisms regarding loneliness as a risk factor for AD and to develop effective prevention or treatment strategies.
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页数：22
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