Sharp cell-type-identity changes differentiate the retrosplenial cortex from the neocortex

被引：7

作者：

Sullivan, Kaitlin E. ^{[1
]}

Kraus, Larissa ^{[1
]}

Kapustina, Margarita ^{[1
]}

Wang, Lihua ^{[2
]}

Stach, Tara R. ^{[3
]}

Lemire, Andrew L. ^{[2
]}

Clements, Jody ^{[2
]}

Cembrowski, Mark S. ^{[1
,2
,4
]}

机构：

[1] Univ British Columbia, Life Sci Inst, Dept Cellular & Physiol Sci, 2350 Hlth Sci Blvd, Vancouver, BC, Canada

[2] Univ British Columbia, Djavad Mowafaghian Ctr Brain Hlth, 2215 Wesbrook Mall, Vancouver, BC, Canada

[3] Univ British Columbia, Biomed Res Ctr, Sch Biomed Engn, 2222 Hlth Sci Mall, Vancouver, BC, Canada

[4] HHMI, Janelia Res Campus,19700 Helix Dr, Ashburn, VA 20147 USA

来源：

CELL REPORTS | 2023年 / 42卷 / 03期

基金：

加拿大自然科学与工程研究理事会; 加拿大健康研究院;

关键词：

CALCIUM; NEURONS; MEMORY; RECONSTRUCTION; ORGANIZATION; TAXONOMY;

D O I：

10.1016/j.celrep.2023.112206

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The laminae of the neocortex are fundamental processing layers of the mammalian brain. Notably, such laminae are believed to be relatively stereotyped across short spatial scales such that shared laminae be-tween nearby brain regions exhibit similar constituent cells. Here, we consider a potential exception to this rule by studying the retrosplenial cortex (RSC), a brain region known for sharp cytoarchitectonic differ-ences across its granular-dysgranular border. Using a variety of transcriptomics techniques, we identify, spatially map, and interpret the excitatory cell-type landscape of the mouse RSC. In doing so, we uncover that RSC gene expression and cell types change sharply at the granular-dysgranular border. Additionally, supposedly homologous laminae between the RSC and the neocortex are effectively wholly distinct in their cell-type composition. In collection, the RSC exhibits a variety of intrinsic cell-type specializations and embodies an organizational principle wherein cell-type identities can vary sharply within and between brain regions.

引用

页数：19

共 62 条

[1] Spatiotemporal patterns of neocortical activity around hippocampal sharp-wave ripples [J].