Biocondensates fuel tumor immune evasion

被引：0
|
作者：
Kubelick, Kelsey P. [1 ,2 ,3 ]
Quiroz, Felipe Garcia [1 ,2 ]
机构：
[1] Georgia Inst Technol, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30332 USA
[2] Emory Univ, Atlanta, GA 30322 USA
[3] Georgia Inst Technol, Sch Elect & Comp Engn, Atlanta, GA USA
来源：
NATURE CANCER | 2023年 / 4卷 / 03期
关键词：
D O I：
10.1038/s43018-023-00520-3
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Transactivation hubs and related biomolecular condensates are emerging as relevant molecular players in cancer biology. A new study now links PD-L1 upregulation on the cancer cell surface and IRF1-KAT8 transactivation hubs at PD-L1 loci. Therapeutic targeting of these hubs holds potential to unleash antitumor immunity.
引用
收藏
页码：312 / 314
页数：3
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