Neutrophil Extracellular Traps and NLRP3 Inflammasome: A Disturbing Duo in Atherosclerosis, Inflammation and Atherothrombosis

被引：23

作者：

Singh, Puneetpal ^{[1
]}

Kumar, Nitin ^{[1
]}

Singh, Monica ^{[1
]}

Kaur, Manminder ^{[2
]}

Singh, Gurjinderpal ^{[3
]}

Narang, Amit ^{[4
]}

Kanwal, Abhinav ^{[5
]}

Sharma, Kirti ^{[1
]}

Singh, Baani ^{[1
]}

Napoli, Mario Di ^{[6
]}

Mastana, Sarabjit ^{[7
]}

机构：

[1] Punjabi Univ, Dept Human Genet, Div Mol Genet, Patiala 147002, India

[2] MK Neuro Ctr, Dept Neurol, Patiala 147002, India

[3] Bhatia Hosp Neuro & Multispecialty, Dept Neurol, Patiala 147002, India

[4] All India Inst Med Sci AIIMS, Dept Neurosurg, Bathinda 151005, India

[5] All India Inst Med Sci AIIMS, Dept Pharmacol, Bathinda 151005, India

[6] Annunziata Hosp, Dept Neurol Serv, I-67039 Sulmona, Laquila, Italy

[7] Loughborough Univ, Sch Sport Exercise & Hlth Sci, Human Genom Lab, Loughborough LE11 3TU, England

来源：

VACCINES | 2023年 / 11卷 / 02期

关键词：

atherosclerosis; inflammation; atherothrombosis; neutrophils; monocytes; macrophages; neutrophil extracellular traps; NLRP3; inflammasome; SMOOTH-MUSCLE-CELLS; ACTIVATION; INTERLEUKIN-18; CHOLESTEROL; MACROPHAGES; EXPRESSION; PATHWAYS; CYTOKINE; CRYSTALS; NETOSIS;

D O I：

10.3390/vaccines11020261

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Atherosclerosis is the formation of plaque within arteries due to overt assemblage of fats, cholesterol and fibrous material causing a blockage of the free flow of blood leading to ischemia. It is harshly impinging on health statistics worldwide because of being principal cause of high morbidity and mortality for several diseases including rheumatological, heart and brain disorders. Atherosclerosis is perpetuated by pro-inflammatory and exacerbated by pro-coagulatory mediators. Besides several other pathways, the formation of neutrophil extracellular traps (NETs) and the activation of the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome contribute significantly to the initiation and propagation of atherosclerotic plaque for its worst outcomes. The present review highlights the contribution of these two disturbing processes in atherosclerosis, inflammation and atherothrombosis in their individual as well as collaborative manner.

引用

页数：15

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