Clinical Outcomes of COVID-19 Infection in Pregnant and Nonpregnant Women: Results from The Philippine CORONA Study

被引:1
|
作者
Espiritu, Adrian I. I. [1 ,2 ,3 ,4 ,5 ]
Bravo, Sybil Lizanne R. [3 ,6 ,7 ,8 ]
Sombilla, Hannah Andrea A. [3 ,6 ]
Tantengco, Ourlad Alzeus G. [9 ,10 ]
Sy, Marie Charmaine C. [2 ,3 ]
Sy, Alvin Duke R.
Anlacan, Veeda Michelle M. [2 ,3 ]
Jamora, Roland Dominic G. [2 ,3 ,11 ]
机构
[1] Univ Philippines Manila, Coll Med, Dept Clin Epidemiol, Manila 1000, Philippines
[2] Univ Philippines Manila, Coll Med, Dept Neurosci, Manila 1000, Philippines
[3] Univ Philippines Manila, Philippine Gen Hosp, Manila 1000, Philippines
[4] Univ Toronto, Div Neurol, M5S, Toronto, ON, Canada
[5] Univ Toronto, Dept Psychiat, M5S, Toronto, ON, Canada
[6] Univ Philippines Manila, Coll Med, Dept Obstet & Gynecol, Manila 1000, Philippines
[7] Manila Doctors Hosp, Dept Obstet & Gynecol, Manila 1000, Philippines
[8] Med Ctr Manila, Dept Obstet & Gynecol, Manila 1000, Philippines
[9] Univ Philippines Manila, Coll Med, Dept Physiol, Manila 1000, Philippines
[10] De La Salle Univ, Coll Sci, Dept Biol, Manila 1004, Philippines
[11] St Lukes Med Ctr, Inst Neurosci, Quezon City 1112, Philippines
关键词
COVID-19; pregnancy; mortality; respiratory failure; ICU admission;
D O I
10.3390/vaccines11020226
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Objective: Our study determined the association of pregnancy with various clinical outcomes among women with COVID-19 infection. Methods: We conducted a retrospective, cohort, subgroup analysis of the Philippine CORONA Study datasets comparing the clinical/neurological manifestations and outcomes of pregnant and nonpregnant women admitted in 37 Philippine hospitals for COVID-19 infection. Results: We included 2448 women in the analyses (322 pregnant and 2.126 nonpregnant). Logistic regression models showed that crude odds ratio (OR) for mortality (OR 0.26 [95% CI 0.11, 0.66]), respiratory failure [OR 0.37 [95% CI 0.17, 0.80]), need for intensive care (OR 0.39 [95% CI 0.19, 0.80]), and prolonged length of hospital stay (OR 1.73 [95% CI 1.36, 2.19]) among pregnant women were significant. After adjusting for age, disease severity, and new-onset neurological symptoms, only the length of hospital stay remained significant (adjusted OR 1.99 [95% CI 1.56,2.54]). Cox regression models revealed that the unadjusted hazard ratio (HR) for mortality (HR 0.22 [95% CI 0.09, 0.55]) among pregnant women was statistically significant; however, after adjustment, the HR for mortality became nonsignificant. Conclusion: We did not find a significantly increased risk of mortality, respiratory failure, and need for ICU admission in pregnant women compared with nonpregnant women with COVID-19. However, the likelihood of hospital confinement beyond 14 days was twice more likely among pregnant women than nonpregnant women with COVID-19.
引用
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页数:11
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