Optochemical control of Cu(i) homeostasis in mammalian cells

被引：3
|
作者：
Pain, Pritam Kumar [1 ]
Palit, Dipanwita [1 ]
Shegane, Meenakshi [1 ]
Singh, Rajnish Pratap [1 ]
Manna, Debasish [1 ]
机构：
[1] Indian Inst Sci Educ & Res Bhopal, Dept Chem, Bhopal Bypass Rd, Bhopal 462066, MP, India
来源：
CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 16期
关键词：
IRON-CHELATION THERAPY; HIGH-AFFINITY; DEFERIPRONE; MECHANISMS;
D O I：
10.1039/d2cc05830h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Copper can act as a double-edged sword as it can cause fatal diseases when in excess or shortage. Precise control of copper homeostasis is maintained by a complex machinery inside cells. To overcome imbalances in copper concentration, we have developed a simple system to control the cellular copper concentration by using a photocaged chelator and light. This photocaged chelator allowed us to control cellular copper concentration in a spatiotemporal manner.
引用
收藏
页码：2315 / 2318
页数：4
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