Optochemical control of Cu(i) homeostasis in mammalian cells

被引：3

作者：

Pain, Pritam Kumar ^{[1
]}

Palit, Dipanwita ^{[1
]}

Shegane, Meenakshi ^{[1
]}

Singh, Rajnish Pratap ^{[1
]}

Manna, Debasish ^{[1
]}

机构：

[1] Indian Inst Sci Educ & Res Bhopal, Dept Chem, Bhopal Bypass Rd, Bhopal 462066, MP, India

来源：

CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 16期

关键词：

IRON-CHELATION THERAPY; HIGH-AFFINITY; DEFERIPRONE; MECHANISMS;

D O I：

10.1039/d2cc05830h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Copper can act as a double-edged sword as it can cause fatal diseases when in excess or shortage. Precise control of copper homeostasis is maintained by a complex machinery inside cells. To overcome imbalances in copper concentration, we have developed a simple system to control the cellular copper concentration by using a photocaged chelator and light. This photocaged chelator allowed us to control cellular copper concentration in a spatiotemporal manner.

引用

页码：2315 / 2318

页数：4

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