Recent advances in ocular graft-versus-host disease

被引：13
|
作者：
Cheng, Xianjing [1 ,2 ]
Huang, Ruihao [1 ]
Huang, Shiqin [1 ]
Fan, Wei [3 ]
Yuan, Rongdi [3 ]
Wang, Xiaoqi [1 ]
Zhang, Xi [1 ,2 ,4 ]
机构：
[1] Army Med Univ, Xinqiao Hosp, State Key Lab Trauma Burns & Combined Injury, Med Ctr Hematol, Chongqing, Peoples R China
[2] Chongqing Univ, Sch Med, Chongqing, Peoples R China
[3] Army Med Univ, Xinqiao Hosp, Dept Ophthalmol, Chongqing, Peoples R China
[4] Jinfeng Lab, Chongqing, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
ocular graft-versus-host-disease; clinical characteristics; the pathogenic mechanism; novel therapeutic targets; tear biomarkers; STEM-CELL TRANSPLANTATION; SERUM EYE DROPS; CONSENSUS DEVELOPMENT PROJECT; MEIBOMIAN GLAND DYSFUNCTION; MESENCHYMAL STROMAL CELLS; DRY EYE; LACRIMAL GLAND; CLINICAL-TRIALS; LONGITUDINAL ANALYSIS; RANDOMIZED-TRIAL;
D O I：
10.3389/fimmu.2023.1092108
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Ocular graft-versus-host-disease (GVHD) remains a significant clinical complication after allogeneic hematopoietic stem cell transplantation. Impaired visual function, pain, and other symptoms severely affect affected individuals' quality of life. However, the diagnosis of and therapy for ocular GVHD involve a multidisciplinary approach and remain challenging for both hematologists and ophthalmologists, as there are no unified international criteria. Through an exploration of the complex pathogenesis of ocular GVHD, this review comprehensively summarizes the pathogenic mechanism, related tear biomarkers, and clinical characteristics of this disease. Novel therapies based on the mechanisms are also discussed to provide insights into the ocular GVHD treatment.
引用
收藏
页数：15
相关论文
共 50 条
  • [21] Challenges and concepts in the diagnosis and management of ocular graft-versus-host disease
    Tappeiner, Christoph
    Heiligenhaus, Arnd
    Halter, Joerg P.
    Miserocchi, Elisabetta
    Bandello, Francesco
    Goldblum, David
    FRONTIERS IN MEDICINE, 2023, 10
  • [22] Impact of Ocular Chronic Graft-versus-Host Disease on Quality of Life
    Sun, Yi-Chen
    Chai, Xiaoyu
    Inamoto, Yoshihiro
    Pidala, Joseph
    Martin, Paul J.
    Flowers, Mary E. D.
    Shen, Tueng T.
    Lee, Stephanie J.
    Jagasia, Madan
    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2015, 21 (09) : 1687 - 1691
  • [23] Graft-versus-host disease: recent advances including the use of photopheresis
    King, K
    Vogelsang, GB
    CURRENT OPINION IN ORGAN TRANSPLANTATION, 2005, 10 (01) : 51 - 58
  • [24] Graft-versus-host disease Part II. Management of cutaneous graft-versus-host disease
    Hymes, Sharon R.
    Alousi, Amin M.
    Cowen, Edward W.
    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2012, 66 (04) : 535 - 552
  • [25] Cutaneous graft-versus-host disease
    Cho, A.
    Just, U.
    Knobler, R.
    HAUTARZT, 2018, 69 (02): : 109 - 115
  • [26] Epidemiology and risk factors for the development of cicatrizing conjunctivitis in chronic ocular graft-versus-host disease
    Kantor, Nicole B.
    Sepulveda-Beltran, Paula A.
    Valdes-Arias, David
    Locatelli, Elyana V. T.
    Mulpuri, Lakshman
    Gunawardene, Araliya N.
    Amescua, Guillermo
    Perez, Victor L.
    Tonk, Rahul
    Wang, Trent
    Galor, Anat
    OCULAR SURFACE, 2024, 34 : 341 - 347
  • [27] A Review of Ocular Graft-versus-Host Disease: Pathophysiology, Clinical Presentation and Management
    Carreno-Galeano, Jimena Tatiana
    Dohlman, Thomas H.
    Kim, Stella
    Yin, Jia
    Dana, Reza
    OCULAR IMMUNOLOGY AND INFLAMMATION, 2021, 29 (06) : 1190 - 1199
  • [28] Lifitegrast ophthalmic solution for treatment of ocular chronic graft-versus-host disease
    Chhabra, Saurabh
    Jerkins, James H.
    Conto, John E.
    Zellner, Katie
    Shah, Nirav N.
    Hari, Parameswaran N.
    Hamadani, Mehdi
    LEUKEMIA & LYMPHOMA, 2020, 61 (04) : 869 - 874
  • [29] Vulvovaginal Graft-Versus-Host Disease
    Kornik, Rachel I.
    Rustagi, Alison S.
    OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA, 2017, 44 (03) : 475 - +
  • [30] Recent advances on cellular therapies and immune modulators for graft-versus-host disease
    Filippini, Perla
    Rutella, Sergio
    EXPERT REVIEW OF CLINICAL IMMUNOLOGY, 2014, 10 (10) : 1357 - 1374
12345