Perspectives on the nanocarriers with miRNAs for targeting melanoma stemness through epigenetic regulation

被引:3
作者
Liu, Junqi [1 ,2 ]
Zhang, Jin [3 ]
Beeraka, Narasimha M. M. [1 ,4 ,5 ]
Chen, Kuo [6 ]
Sinelnikov, Mikhail Y. Y. [4 ]
Manogaran, Prasath [7 ]
Bannimath, Gurupadayya [5 ]
Nikolenko, Vladimir N. N. [4 ,8 ]
Fan, Ruitai [1 ,2 ,9 ]
机构
[1] Zhengzhou Univ, Affiliated Hosp 1, Canc Ctr, Zhengzhou, Peoples R China
[2] Zhengzhou Univ, Affiliated Hosp 1, Dept Radiat Oncol, Zhengzhou, Peoples R China
[3] Univ Mississippi, Med Ctr, Dept Pharmacol & Toxicol, Jackson, MS USA
[4] IM Sechenov First Moscow State Med Univ, Sechenov Univ, Dept Human Anat, Moscow, Russia
[5] JSS Acad Higher Educ & Res JSS AHER, JSS Coll Pharm, Dept Pharmaceut Chem, Mysore, India
[6] Zhengzhou Univ, Affiliated Hosp 1, Dept Breast Surg, Zhengzhou, Peoples R China
[7] Bharathiar Univ Coimbatore, Dept Biotechnol, Coimbatore, India
[8] Moscow MV Lomonosov State Univ, Moscow, Russia
[9] Zhengzhou Univ, Affiliated Hosp 1, Canc Ctr, 1 Jianshedong St, Zhengzhou 450052, Peoples R China
基金
中国国家自然科学基金;
关键词
melanoma; epigenetics; miRNAs; nanodelivery; signaling pathways; stemness; GENOME-WIDE SCREEN; TUMOR-SUPPRESSOR; CELL-PROLIFERATION; NATURAL-PRODUCTS; DNA-METHYLATION; DOWN-REGULATION; GAMBOGIC ACID; POLYETHYLENIMINE COMPLEXES; PROMOTER METHYLATION; PROSTATE-CANCER;
D O I
10.1111/pcmr.13081
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Several research reports delineated the significant role of miRNAs in cancer proliferation, and their modulatory role in cancer mitigation, and drug resistance. Melanoma cells have been acquiring stemness to several chemotherapeutic agents through drug efflux proteins, epigenetic modulation, and DNA repair. miRNAs could be applied as novel therapeutic modalities for treating several kinds of cancers to modulate these mechanisms involved in stemness. Nanocarriers to carry these tumor-targeting miRNAs to modulate stemness are a prominent strategy to overcome their low penetrability, minimal stability, and nonspecificity. We have searched several public databases such as PubMed, Medline, Google scholar, and NLM and obtained the information pertinent to the miRNA-based nanocarrier systems to target stemness through epigenetic modulation in melanomas. This review delineates that various miRNAs can modulate the stemness in melanomas by specific intricate epigenetic signaling, and other cell-based signaling mechanisms. Specific nanocarrier formulations with specific miRNAs are optimal methods to deliver these miRNAs in order to achieve significant entrapment efficiency, loading efficiency, and stability. Furthermore, the combinatorial regimen of FDA-approved chemotherapeutic molecules with tumor-targeting miRNAs and chemotherapy combined with nanocarriers can efficiently deliver the utmost therapeutic window by targeting tumor matrix, invasion, metastasis, and angiogenesis in melanomas. Substantial research should focus on the clinical application of this gene therapy in melanomas using these low immunogenic, highly degradable, and biocompatible combinatorial nanotherapeutic regimens.
引用
收藏
页码:268 / 287
页数:21
相关论文
共 158 条
  • [1] Abdussalam-Mohammed W., 2020, Adv J Chem Sect A, V3, P111, DOI [10.33945/SAMI/AJCA.2020.2.8, DOI 10.33945/SAMI/AJCA.2020.2.8]
  • [2] Acunzo Mario, 2015, Adv Biol Regul, V57, P1, DOI 10.1016/j.jbior.2014.09.013
  • [3] Differences in microRNA expression between melanoma and healthy adjacent skin
    Aksenenko, Mariya
    Palkina, Nadezhda
    Komina, Anna
    Tashireva, Liubov
    Ruksha, Tatiana
    [J]. BMC DERMATOLOGY, 2019, 19
  • [4] Alnuqaydan AM, 2020, AM J TRANSL RES, V12, P3531
  • [5] Alnuqaydan AM, 2020, AM J CANCER RES, V10, P799
  • [6] Tamarix articulata (T. articulata) - An Important Halophytic Medicinal Plant with Potential Pharmacological Properties
    Alnuqaydan, Abdullah M.
    Rah, Bilal
    [J]. CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2019, 20 (04) : 285 - 292
  • [7] Recent advances in malignant melanoma
    Atkinson, Victoria
    [J]. INTERNAL MEDICINE JOURNAL, 2017, 47 (10) : 1114 - 1121
  • [8] The future of epigenetic therapy in solid tumours-lessons from the past
    Azad, Nilofer
    Zahnow, Cynthia A.
    Rudin, Charles M.
    Baylin, Stephen B.
    [J]. NATURE REVIEWS CLINICAL ONCOLOGY, 2013, 10 (05) : 256 - 266
  • [9] The relationship between pH and zeta potential of ∼ 30 nm metal oxide nanoparticle suspensions relevant to in vitro toxicological evaluations
    Berg, J. Michael
    Romoser, Amelia
    Banerjee, Nivedita
    Zebda, Rema
    Sayes, Christie M.
    [J]. NANOTOXICOLOGY, 2009, 3 (04) : 276 - 283
  • [10] Epigenetics of human melanoma: promises and challenges
    Besaratinia, Ahmad
    Tommasi, Stella
    [J]. JOURNAL OF MOLECULAR CELL BIOLOGY, 2014, 6 (05) : 356 - 367