The role of complement C3 in the outcome of regional myocardial infarction

被引：8
作者：
Fang, Zhou [1 ]
Li, Xiang [1 ]
Liu, Junying [1 ]
Lee, Haekyung [1 ]
Salciccioli, Louis [3 ]
Lazar, Jason [3 ]
Zhang, Ming [1 ,2 ,4 ]
机构：
[1] Dept Anesthesiol, Brooklyn, NY USA
[2] Dept Cell Biol, Brooklyn, NY USA
[3] SUNY Downstate Hlth Sci Univ, Dept Med, 450 Clarkson Ave, Brooklyn, NY 11203 USA
[4] SUNY Downstate Hlth Sci Univ, Dept Anesthesiol, MSC6, 450 Clarkson Ave, Brooklyn, NY 11203 USA
来源：
BIOCHEMISTRY AND BIOPHYSICS REPORTS | 2023年 / 33卷
关键词：
Ischemia; reperfusion injury (IRI); Complement C3; Necrosis; Cardiac fibrosis; 1; PERCUTANEOUS CORONARY INTERVENTION; ST-ELEVATION; EJECTION FRACTION; HEART-FAILURE; REPERFUSION; ACTIVATION; MECHANISMS; MANAGEMENT; ISCHEMIA; IMMUNE;
D O I：
10.1016/j.bbrep.2023.101434
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Coronary heart disease leading to myocardial ischemia is a major cause of heart failure. A hallmark of heart failure is myocardial fibrosis. Using a murine model of myocardial ischemia/reperfusion injury (IRI), we showed that, following IRI, in mice genetically deficient in the central factor of complement system, C3, myocardial necrosis was reduced compared with WT mice. Four weeks after the ischemic period, the C3-/- mice had significantly less cardiac fibrosis and better cardiac function than the WT controls. Overall, our results suggest that innate immune response through complement C3 plays an important role in necrotic cell death, which contributes to the cardiac fibrosis that underlies post-infarction heart failure.
引用
收藏
页数：6
相关论文
共 65 条
[11]   Loss of plasma membrane integrity, complement response and formation of reactive oxygen species during early myocardial ischemia/reperfusion [J].
Charlagorla, Pradeepkumar ;
Liu, Junying ;
Patel, Monaliben ;
Rushbrook, Julie I. ;
Zhang, Ming .
MOLECULAR IMMUNOLOGY, 2013, 56 (04) :507-512
[12]   Biomarkers of heart failure with normal ejection fraction: a systematic review [J].
Cheng, Jin M. ;
Akkerhuis, K. Martijn ;
Battes, Linda C. ;
van Vark, Laura C. ;
Hillege, Hans L. ;
Paulus, Walter J. ;
Boersma, Eric ;
Kardys, Isabella .
EUROPEAN JOURNAL OF HEART FAILURE, 2013, 15 (12) :1350-1362
[13]   Cardiomyocyte death: mechanisms and translational implications [J].
Chiong, M. ;
Wang, Z. V. ;
Pedrozo, Z. ;
Cao, D. J. ;
Troncoso, R. ;
Ibacache, M. ;
Criollo, A. ;
Nemchenko, A. ;
Hill, J. A. ;
Lavandero, S. .
CELL DEATH & DISEASE, 2011, 2 :e244-e244
[14]   COMPLEMENT AND NEUTROPHIL ACTIVATION IN THE PATHOGENESIS OF ISCHEMIC MYOCARDIAL INJURY [J].
CRAWFORD, MH ;
GROVER, FL ;
KOLB, WP ;
MCMAHAN, CA ;
OROURKE, RA ;
MCMANUS, LM ;
PINCKARD, RN .
CIRCULATION, 1988, 78 (06) :1449-1458
[15]   Molecular mechanisms that control interstitial fibrosis in the pressure-overloaded heart [J].
Creemers, Esther E. ;
Pinto, Yigal M. .
CARDIOVASCULAR RESEARCH, 2011, 89 (02) :265-272
[16]   AMPK in cardiac fibrosis and repair: Actions beyond metabolic regulation [J].
Daskalopoulos, Evangelos P. ;
Dufeys, Cecile ;
Bertrand, Luc ;
Beauloye, Christophe ;
Horman, Sandrine .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2016, 91 :188-200
[17]   Leucocyte expression of complement C5a receptors exacerbates infarct size after myocardial reperfusion injury [J].
De Hoog, Vince C. ;
Timmers, Leo ;
Van Duijvenvoorde, Amerik ;
De Jager, Saskia C. A. ;
Van Middelaar, Ben J. ;
Smeets, Mirjam B. ;
Woodruff, Trent M. ;
Doevendans, Pieter A. ;
Pasterkamp, Gerard ;
Hack, C. Erik ;
De Kleijn, Dominique P. V. .
CARDIOVASCULAR RESEARCH, 2014, 103 (04) :521-529
[18]   Total Ischemic Time The Correct Focus of Attention for Optimal ST-Segment Elevation Myocardial Infarction Care [J].
Denktas, Ali E. ;
Anderson, H. Vernon ;
McCarthy, James ;
Smalling, Richard W. .
JACC-CARDIOVASCULAR INTERVENTIONS, 2011, 4 (06) :599-604
[19]   Complement and its role in innate and adaptive immune responses [J].
Dunkelberger, Jason R. ;
Song, Wen-Chao .
CELL RESEARCH, 2010, 20 (01) :34-50
[20]   Positive Transcription Elongation Factor b Activity in Compensatory Myocardial Hypertrophy is Regulated by Cardiac Lineage Protein-1 [J].
Espinoza-Derout, Jorge ;
Wagner, Michael ;
Salciccioli, Louis ;
Lazar, Jason M. ;
Bhaduri, Sikha ;
Mascareno, Eduardo ;
Chaqour, Brahim ;
Siddiqui, M. A. Q. .
CIRCULATION RESEARCH, 2009, 104 (12) :1347-U189
1234567