Impact of dupilumab on patch test results and allergic contact dermatitis: A prospective multicenter study

被引：5

作者：

Bocquel, Sarah ^{[1
]}

Soria, Angele ^{[2
]}

Raison-Peyron, Nadia ^{[3
]}

Badaoui, Antoine ^{[4
]}

Marcant, Pierre ^{[5
]}

Bara, Corina ^{[6
]}

Giordano-Labadie, Francoise ^{[7
]}

Amsler, Emmanuelle ^{[8
]}

Milpied, Brigitte ^{[8
]}

Delaunay, Juliette ^{[9
]}

Darrigade, Anne-Sophie ^{[10
]}

Pralong, Pauline ^{[11
]}

Boulard, Claire ^{[12
]}

Bouedec, Marie-Christine Ferrier Le ^{[13
]}

Tauber, Marie ^{[7
]}

Pasteur, Justine ^{[13
]}

Valois, Aude ^{[14
]}

Le Thuaur, Aurelie ^{[15
]}

Crepy, Marie-Noelle ^{[16
]}

Bernier, Claire ^{[1
,17
]}

机构：

[1] Nantes Univ Hosp, Dept Dermatol, Nantes, France

[2] Medecine Sorbonne Univ, Hosp Tenon, Assistance Publ Hop Paris AP HP, Serv Dermatol & Allergol,Dermatol & allergy Dept,T, Paris, France

[3] CHU Montpellier, Dept Dermatol, Montpellier, France

[4] Hop Instruct Armees Begin, Dept Dermatol, St Mande, France

[5] CHU Lille, Dept Dermatol, Lille, France

[6] CH Le Mans, Dept Dermatol, Le Mans, France

[7] CHU Toulouse, Dept Dermatol, Toulouse, France

[8] Hop St Andre, Dept Dermatol, Bordeaux, France

[9] CHU Angers, Dept Dermatol, Angers, France

[10] CHU Bordeaux, Dept Dermatol, Bordeaux, France

[11] CHU Grenoble, Dept allergol, Grenoble, France

[12] CH Jacques Monod, Dept Dermatol, Le Havre, France

[13] CHU Clermont Ferrand, Dept Dermatol, Clermont Ferrand, France

[14] HIA, Dept Dermatol, Toulon, France

[15] CHU Nantes, Res Dept, Nantes, France

[16] Hop Hotel Dieu, Dept Occupat & Environm Dis, Paris, France

[17] Nantes Univ Hosp Hotel Dieu, Dept Dermatol, 1 Pl Alexis Ricordeau, F-44093 Nantes, France

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2024年 / 90卷 / 03期

关键词：

ATOPIC-DERMATITIS; THERAPY;

D O I：

10.1016/j.jaad.2023.10.029

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: Limited and conflicting data have been reported on the impact of dupilumab (DUPI) on patch test (PT) results and its efficacy against allergic contact dermatitis (ACD). Objective: This study was undertaken to analyze PT reactivities and relevance during treatment with DUPI to determine whether they could detect ACD in patients with uncontrolled or worsened atopic dermatitis (AD) who were receiving this agent. Methods: This prospective, multicenter study examined 76 DUPI-treated patients who had undergone PTs. The relevant information was collected during 3 visits. Results: Overall, 36 patients (47%) had >= 1 positive PT reaction, and 142 PT results were positive. Twentythree patients (30%) had >= 1 positive and clinically relevant PT result. Five of them had clinical eczema improvement after allergen avoidance. We compared the PT results of 36 patients before and during DUPI therapy, representing 1230 paired PT allergens, of which 1022 were the same, 34 were positive, 44 were lost, and 130 were uninterpretable. Limitations: Because the number of patients included remains limited, our findings should be confirmed with a larger sample. Conclusion: Our results confirmed the usefulness of PTs for patients receiving DUPI, with good PT reproducibility. We suggest that all DUPI-treated patients with AD developing partial responses or experiencing symptom worsening should undergo PTs to look for contact sensitization. ( J Am Acad Dermatol 2024;90:512-20.)

引用

页码：512 / 520

页数：9

共 26 条

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