Vaccination from the early second trimester onwards gives a robust SARS-CoV-2 antibody response throughout pregnancy and provides antibodies for the neonate

被引：15

作者：

Zilver, Sanne J. M. ^{[1
,2
]}

de Groot, Christianne J. M. ^{[2
,3
]}

Grobben, Marloes ^{[4
,5
]}

Remmelzwaal, Sharon ^{[6
]}

Burgers, Esmee ^{[1
]}

Velasco, Daniela Nunez ^{[3
]}

Juncker, Hannah G. ^{[2
,7
]}

van Keulen, Britt J. ^{[2
,7
]}

van Goudoever, Johannes B. ^{[2
,7
]}

de Leeuw, Robert A. ^{[3
]}

van Gils, Marit J. ^{[4
,5
]}

Ris-Stalpers, Carrie ^{[2
,3
]}

van Leeuwen, Elisabeth ^{[2
,3
]}

机构：

[1] Vrije Univ Amsterdam, Amsterdam UMC locat, Dept Obstet & gynecol, Amsterdam, Netherlands

[2] Amsterdam Reprod & Dev Res Inst, Amsterdam, Netherlands

[3] Univ Amsterdam, Amsterdam UMC locat, Dept Obstet & gynecol, Amsterdam, Netherlands

[4] Univ Amsterdam, Dept Med Microbiol, Amsterdam UMC, Amsterdam, Netherlands

[5] Amsterdam Inst Infect & Immun Infect Dis, Amsterdam, Netherlands

[6] Vrije Univ Amsterdam, Amsterdam UMC locat, Epidemiol & Data Sci, Amsterdam, Netherlands

[7] Univ Amsterdam, Vrije Univ, Amsterdam UMC locat, Dept Pediat,Emma Childrens Hosp, Amsterdam, Netherlands

来源：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2023年 / 130卷

关键词：

COVID-19; Antispike IgG; Virus neutralization; Pregnancy; Placental antibody transfer; Vaccination; COVID-19; WOMEN;

D O I：

10.1016/j.ijid.2023.02.022

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Objectives: Preventive measures against COVID-19 are essential for pregnant women. Pregnant women are particularly vulnerable to emerging infectious pathogens due to alterations in their physiology. We aimed to determine the optimum timing of vaccination to protect pregnant women and their neonates from COVID-19.Methods: A prospective observational longitudinal cohort study in pregnant women who received COVID19 vaccination. We collected blood samples to evaluate levels of antispike, receptor binding domain and nucleocapsid antibodies against SARS-CoV-2 before vaccination and 15 days after the first and second vaccination. We determined the neutralizing antibodies from mother-infant dyads in maternal and umbilical cord blood at birth. If available, immunoglobulin A was measured in human milk.Results: We included 178 pregnant women. Median antispike immunoglobulin G levels increased significantly from 1.8 to 5431 binding antibody units/ml and receptor binding domain from 6 to 4466 binding antibody units/ml. Virus neutralization showed similar results between different weeks of gestation at vaccination ( P > 0.3).Conclusion: We advise vaccination in the early second trimester of pregnancy for the optimum balance between the maternal antibody response and placental antibody transfer to the neonate.& COPY; 2023 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )

引用

页码：126 / 135

页数：10

共 42 条

[1] Time since SARS-CoV-2 infection and humoral immune response following BNT162b2 mRNA vaccination [J].

Appelman, Brent ;

van der Straten, Karlijn ;

Lavell, A. H. Ayesha ;

Schinkel, Michiel ;

Slim, Marleen A. ;

Poniman, Meliawati ;

Burger, Judith A. ;

Oomen, Melissa ;

Tejjani, Khadija ;

Vlaar, Alexander P. J. ;

Wiersinga, W. Joost ;

Smulders, Yvo M. ;

van Vught, Lonneke A. ;

Sanders, Rogier W. ;

van Gils, Marit J. ;

Bomers, Marije K. ;

Sikkens, Jonne J. .

EBIOMEDICINE, 2021, 72

[2] COVID-19 mRNA vaccines drive differential antibody Fc-functional profiles in pregnant, lactating, and nonpregnant women [J].

Atyeo, Caroline ;

DeRiso, Elizabeth A. ;

Davis, Christine ;

Bordt, Evan A. ;

De Guzman, Rose M. ;

Shook, Lydia L. ;

Yonker, Lael M. ;

Fasano, Alessio ;

Akinwunmi, Babatunde ;

Lauffenburger, Douglas A. ;

Elovitz, Michal A. ;

Gray, Kathryn J. ;

Edlow, Andrea G. ;

Alter, Galit .

SCIENCE TRANSLATIONAL MEDICINE, 2021, 13 (617)

[3] Maternal immune response and placental antibody transfer after COVID-19 vaccination across trimester and platforms [J].

Atyeo, Caroline G. ;

Shook, Lydia L. ;

Brigida, Sara ;

De Guzman, Rose M. ;

Demidkin, Stepan ;

Muir, Cordelia ;

Akinwunmi, Babatunde ;

Baez, Arantxa Medina ;

McSweeney, Erin ;

Burns, Madeleine ;

Nayak, Ruhi ;

Kumar, Maya K. ;

Patel, Chinmay D. ;

Fialkowski, Allison ;

Cvrk, Dana ;

Goldfarb, Ilona T. ;

Yonker, Lael M. ;

Fasano, Alessio ;

Balazs, Alejandro B. ;

Elovitz, Michal A. ;

Gray, Kathryn J. ;

Alter, Galit ;

Edlow, Andrea G. .

NATURE COMMUNICATIONS, 2022, 13 (01)

[4]

Beharier O, 2021, J CLIN INVEST, V131, DOI [10.1172/JCI154834, 10.1172/JCI150319]

[5] COVID-19 vaccination during pregnancy: coverage and safety [J].

Blakeway, Helena ;

Prasad, Smriti ;

Kalafat, Erkan ;

Heath, Paul T. ;

Ladhani, Shamez N. ;

Le Doare, Kirsty ;

Magee, Laura A. ;

O'Brien, Pat ;

Rezvani, Arezou ;

von Dadelszen, Peter ;

Khalil, Asma .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2022, 226 (02) :236.e1-236.e14

[6] COVID-19 Vaccine Considerations during Pregnancy and Lactation [J].

Blumberg, Dean ;

Sridhar, Aparna ;

Lakshminrusimha, Satyan ;

Higgins, Rosemary D. ;

Saade, George .

AMERICAN JOURNAL OF PERINATOLOGY, 2021, 38 (06) :523-528

[7] Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection [J].

Brouwer, Philip J. M. ;

Brinkkemper, Mitch ;

Maisonnasse, Pauline ;

Dereuddre-Bosquet, Nathalie ;

Grobben, Marloes ;

Claireaux, Mathieu ;

de Gast, Marlon ;

Marlin, Romain ;

Chesnais, Virginie ;

Diry, Segolene ;

Allen, Joel D. ;

Watanabe, Yasunori ;

Giezen, Julia M. ;

Kerster, Gius ;

Turner, Hannah L. ;

van der Straten, Karlijn ;

van der Linden, Cynthia A. ;

Aldon, Yoann ;

Naninck, Thibaut ;

Bontjer, Ilja ;

Burger, Judith A. ;

Poniman, Meliawati ;

Mykytyn, Anna Z. ;

Okba, Nisreen M. A. ;

Schermer, Edith E. ;

van Breemen, Marielle J. ;

Ravichandran, Rashmi ;

Caniels, Tom G. ;

van Schooten, Jelle ;

Kahlaoui, Nidhal ;

Contreras, Vanessa ;

Lemaitre, Julien ;

Chapon, Catherine ;

Fang, Raphael Ho Tsong ;

Villaudy, Julien ;

Sliepen, Kwinten ;

van der Velden, Yme U. ;

Haagmans, Bart L. ;

de Bree, Godelieve J. ;

Ginoux, Eric ;

Ward, Andrew B. ;

Crispin, Max ;

King, Neil P. ;

van der Werf, Sylvie ;

van Gils, Marit J. ;

Le Grand, Roger ;

Sanders, Rogier W. .

CELL, 2021, 184 (05) :1188-+

[8] Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability [J].

Brouwer, Philip J. M. ;

Caniels, Tom G. ;

van der Straten, Karlijn ;

Snitselaar, Jonne L. ;

Aldon, Yoann ;

Bangaru, Sandhya ;

Torres, Jonathan L. ;

Okba, Nisreen M. A. ;

Claireaux, Mathieu ;

Kerster, Gius ;

Bentlage, Arthur E. H. ;

van Haaren, Marlies M. ;

Guerra, Denise ;

Burger, Judith A. ;

Schermer, Edith E. ;

Verheul, Kirsten D. ;

van der Velde, Niels ;

van der Kooi, Alex ;

van Schooten, Jelle ;

van Breemen, Marielle J. ;

Bijl, Tom P. L. ;

Sliepen, Kwinten ;

Aartse, Aafke ;

Derking, Ronald ;

Bontjer, Ilja ;

Kootstra, Neeltje A. ;

Wiersinga, W. Joost ;

Vidarsson, Gestur ;

Haagmans, Bart L. ;

Ward, Andrew B. ;

de Bree, Godelieve J. ;

Sanders, Rogier W. ;

van Gils, Marit J. .

SCIENCE, 2020, 369 (6504) :643-+

[9] Characteristics and Outcomes of Women With COVID-19 Giving Birth at US Academic Centers During the COVID-19 Pandemic [J].

Chinn, Justine ;

Sedighim, Shaina ;

Kirby, Katharine A. ;

Hohmann, Samuel ;

Hameed, Afshan B. ;

Jolley, Jennifer ;

Nguyen, Ninh T. .

JAMA NETWORK OPEN, 2021, 4 (08)

[10] Immunogenicity of COVID-19 mRNA Vaccines in Pregnant and Lactating Women [J].

Collier, Ai-ris Y. ;

McMahan, Katherine ;

Yu, Jingyou ;

Tostanoski, Lisa H. ;

Aguayo, Ricardo ;

Ansel, Jessica ;

Chandrashekar, Abishek ;

Patel, Shivani ;

Apraku Bondzie, Esther ;

Sellers, Daniel ;

Barrett, Julia ;

Sanborn, Owen ;

Wan, Huahua ;

Chang, Aiquan ;

Anioke, Tochi ;

Nkolola, Joseph ;

Bradshaw, Connor ;

Jacob-Dolan, Catherine ;

Feldman, Jared ;

Gebre, Makda ;

Borducchi, Erica N. ;

Liu, Jinyan ;

Schmidt, Aaron G. ;

Suscovich, Todd ;

Linde, Caitlyn ;

Alter, Galit ;

Hacker, Michele R. ;

Barouch, Dan H. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2021, 325 (23) :2370-2380

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