Evaluation of whole blood thiamine pyrophosphate concentrations in critically ill patients receiving chronic diuretic therapy prior to admission to Turkish intensive care units: A pragmatic, multicenter, prospective study

被引：4

作者：

Gundogan, Kursat ^{[1
,2
,20
]}

Sahin, Gulsah G. ^{[2
]}

Ergul, Serap S. ^{[2
]}

Ozer, Nurhayat T. ^{[2
]}

Temel, Sahin ^{[1
]}

Akbas, Turkay ^{[3
]}

Ercan, Talha ^{[3
]}

Yildiz, Hamit ^{[4
]}

Dizdar, Oguzhan S. ^{[5
]}

Simsek, Zuhal ^{[5
]}

Aydin, Kaniye ^{[5
]}

Ulu, Ramazan ^{[6
]}

Zerman, Avsar ^{[7
]}

Dal, Hayriye C. ^{[8
]}

Aydin, Emre ^{[9
]}

Ozyilmaz, Ezgi ^{[10
]}

Ates, Nazire ^{[10
]}

Gonderen, Kamil ^{[11
]}

Yalcin, Nazif ^{[11
]}

Topeli, Arzu ^{[12
]}

Tok, Gulay ^{[12
]}

Edipoglu, Ozlem ^{[13
]}

Ergan, Begum ^{[14
]}

Aydemir, Ferhan D. ^{[15
]}

Akbudak, Ismail H. ^{[16
]}

Ergun, Recai ^{[17
]}

Yuksel, Recep C. ^{[1
]}

Sungur, Murat ^{[1
,2
]}

Griffith, Daniel P. ^{[18
]}

Ziegler, Thomas R. ^{[18
,19
]}

机构：

[1] Erciyes Univ, Dept Internal Med, Div Intens Care Med, Sch Med, Kayseri, Turkiye

[2] Erciyes Univ, Dept Clin Nutr, Hlth Sci Inst, Kayseri, Turkiye

[3] Duzce Univ, Dept Internal Med, Div Intens Care Med, Sch Med, Duzce, Turkiye

[4] Gaziantep Univ, Fac Med, Dept Internal Med, Gaziantep, Turkiye

[5] Kayseri Training & Res Hosp, Dept Internal Med, Kayseri, Turkiye

[6] Firat Med Fac, Dept Nephrol, Elazig, Turkiye

[7] Kirsehir Ahi Evran Univ, Dept Intens Care Unit, Kirsehir, Turkiye

[8] Turkiye Yuksek Ihtisas Training & Res Hosp, Dept Intens Care Unit, Ankara, Turkiye

[9] Dicle Univ, Sch Med, Dept Nephrol, Diyarbakir, Turkiye

[10] Cukurova Univ, Dept Internal Med, Div Intens Care Med, Sch Med, Adana, Turkiye

[11] Kutahya Evliya Celebi Training & Res Hosp, Clin Intens Care Unit, Kutahya, Turkiye

[12] Hacettepe Univ, Dept Internal Med, Div Intens Care Med, Sch Med, Ankara, Turkiye

[13] Hlth Sci Univ, Izmir Dr Suat Seren Chest Dis & Thorac Surg Traini, Dept Intens Care Unit, Izmir, Turkiye

[14] Dokuz Eylul Univ, Dept Internal Med, Div Intens Care Med, Sch Med, Izmir, Turkiye

[15] Canakkale Mehmet Akif Ersoy State Hosp, Div Intens Care Med, Canakkale, Turkiye

[16] Pamukkale Univ, Dept Internal Med, Div Intens Care Med, Sch Med, Denizli, Turkiye

[17] Selcuk Univ, Dept Chest Dis, Fac Med, Konya, Turkiye

[18] Emory Univ Hosp, Nutr & Metab Support Serv, Atlanta, GA USA

[19] Emory Univ, Dept Med, Div Endocrinol Metab & Lipids, Sch Med, Atlanta, GA USA

[20] Erciyes Univ, Dept Med, Div Med Intens Care, Sch Med, TR-38039 Kayseri, Turkiye

来源：

JOURNAL OF CRITICAL CARE | 2023年 / 77卷

关键词：

Critical illness; Diuretics; Refeeding syndrome; Thiamine; DEFICIENCY; ENCEPHALOPATHY; MORTALITY; SCORE;

D O I：

10.1016/j.jcrc.2023.154326

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Background/Objectives: Thiamine plays a pivotal role in energy metabolism. The aim of the study was to deter-mine serial whole blood TPP concentrations in critically ill patients receiving chronic diuretic treatment before ICU admission and to correlate TPP levels with clinically determined serum phosphorus concentrations.Subjects/Methods: This observational study was performed in 15 medical ICUs. Serial whole blood TPP concen-trations were measured by HPLC at baseline and at days 2, 5 and 10 after ICU admission. Results: A total of 221 participants were included. Of these, 18% demonstrated low TPP concentrations upon admission to the ICU, while 26% of participants demonstrated low levels at some point during the 10-day study period. Hypophosphatemia was detected in 30% of participants at some point during the 10-day period of observation. TPP levels were significantly and positively correlated with serum phosphorus levels at each time point (P < 0.05 for all).Conclusions: Our results show that 18% of these critically ill patients exhibited low whole blood TPP concen-trations on ICU admission and 26% had low levels during the initial 10 ICU days, respectively. The modest correlation between TPP and phosphorus concentrations suggests a possible association due to a refeeding effect in ICU patients requiring chronic diuretic therapy.

引用

页数：6

共 3 条

[1] Thiamin Status in Adults Receiving Chronic Diuretic Therapy Prior to Admission to a Medical Intensive Care Unit: A Pilot Study
Gundogan, Kursat
Akbudak, Ismail Hakki
Bulut, Kadir
Temel, Sahin
Sungur, Murat
Guven, Muhammet
Dave, Nisha J.
Griffith, Daniel P.
Ziegler, Thomas R.
NUTRITION IN CLINICAL PRACTICE, 2019, 34 (04) : 565 - 571
[2] The mode and timing of administrating nutritional treatment of critically ill elderly patients in intensive care units: a multicenter prospective study
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Peng, Milin
Ye, Zhiwen
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Liu, Zhiyong
FRONTIERS IN MEDICINE, 2024, 11
[3] Insulin therapy and blood glucose management in critically ill patients: a 1-day cross-sectional observational study in 69 French intensive care units
Desgrouas, Maxime
Demiselle, Julien
Stiel, Laure
Brunot, Vincent
Marnai, Remy
Sarfati, Sacha
Fiancette, Maud
Lambiotte, Fabien
Thille, Arnaud W.
Leloup, Maxime
Clerc, Sebastien
Beuret, Pascal
Bourion, Anne-Astrid
Daum, Johan
Malhomme, Remi
Ravan, Ramin
Sauneuf, Bertrand
Rigaud, Jean-Philippe
Dequin, Pierre-Francois
Boulain, Thierry
ANNALS OF INTENSIVE CARE, 2023, 13 (01)

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