Emerging applications of extracellular vesicles in tumor therapy

被引：4
作者：
Luo, Hui [1 ,2 ]
Jin, Jing [3 ]
Jin, Jiajia [4 ]
Lou, Kecheng [1 ,2 ]
He, Hailan [1 ,2 ]
Feng, Shangzhi [1 ,2 ]
Zeng, Fei [1 ]
Zou, Junrong [2 ]
机构：
[1] Gannan Med Univ, Clin Coll 1, Ganzhou, Jiangxi, Peoples R China
[2] Gannan Med Univ, Affiliated Hosp 1, Dept Urol, Ganzhou, Jiangxi, Peoples R China
[3] Dongyang Maternal & Child Hlth Hosp, Dept Gynecol, Jinhua, Zhejiang, Peoples R China
[4] Dongyang Weishan Town Cent Hlth Hosp, Jinhua, Zhejiang, Peoples R China
来源：
CANCER NANOTECHNOLOGY | 2023年 / 14卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Extracellular vesicles; Exosomes; Nanotechnology; Drug delivery; Tumor therapy; MESENCHYMAL STEM-CELLS; MACROPHAGE-DERIVED EXOSOMES; DRUG-DELIVERY-SYSTEMS; IN-VITRO; BREAST-CANCER; STROMAL CELLS; BONE-MARROW; PLANT; PACLITAXEL; INHIBIT;
D O I：
10.1186/s12645-023-00217-3
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Extracellular vesicles (EVs) have tremendous potential as nano/micron-sized drug delivery carriers. Their physical, chemical and biological characteristics distinguish them as unique carriers with specific pharmacokinetic, circulating metabolic, and biodistribution patterns in the delivery of therapeutic cargoes. They are critical mediators in the pathology of many diseases, including inflammatory diseases, fibrosis, and cancer, but they are also essential mediators in immunomodulation, cancer treatment, infectious defense, and tissue repair. In this review, we emphasize recent advances in oncology therapy using macrophage EVs, mesenchymal stem cell EVs, milk EVs, and plant EVs, as well as the advantages of EVs as delivery platforms and their prospective clinical applications and use.
引用
收藏
页数：25
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