Mucosal vaccines for SARS-CoV-2: scientific gaps and opportunities-workshop report

被引：67

作者：

Knisely, Jane M. ^{[1
,2
]}

Buyon, Lucas E. ^{[3
]}

Mandt, Rebecca ^{[3
]}

Farkas, Rebecca ^{[4
]}

Balasingam, Shobana ^{[5
]}

Bok, Karin ^{[6
]}

Buchholz, Ursula J. ^{[7
]}

D'Souza, M. Patricia ^{[8
]}

Gordon, Jennifer L. ^{[2
]}

King, Deborah F. L. ^{[5
]}

Le, Tung T. ^{[4
]}

Leitner, Wolfgang W. ^{[9
]}

Seder, Robert A. ^{[6
]}

Togias, Alkis ^{[9
]}

Tollefsen, Stig ^{[4
]}

Vaughn, David W. ^{[10
]}

Wolfe, Daniel N. ^{[11
]}

Taylor, Kimberly L. ^{[2
]}

Fauci, Anthony S. ^{[1
]}

机构：

[1] Natl Inst Allergy & Infect Dis, NIH, Bethesda, MD 20892 USA

[2] Natl Inst Allergy & Infect Dis, Div Microbiol & Infect Dis, NIH, Bethesda, MD 20892 USA

[3] Natl Inst Allergy & Infect Dis, Off Sci Management & Operat, NIH, Bethesda, MD 20892 USA

[4] Skoyen Atrium, Coalit Epidem Preparedness Innovat, Askekroken 11, N-0277 Oslo, Norway

[5] Infect Dis Prevent Wellcome Trust, London NW1 2BE, England

[6] Natl Inst Allergy & Infect Dis, Vaccine Res Ctr, NIH, Bethesda, MD USA

[7] Natl Inst Allergy & Infect Dis, Lab Infect Dis, RNA Viruses Sect, NIH, Bethesda, MD 20892 USA

[8] Natl Inst Allergy & Infect Dis, Div AIDS, NIH, Rockville, MD USA

[9] Natl Inst Allergy & Infect Dis, Div Allergy Immunol & Transplantat, Rockville, MD USA

[10] Bill & Melinda Gates Fdn, Seattle, WA USA

[11] Biomed Adv Res & Dev Author, Adm Strateg Preparedness & Response, 200 C St SW, Washington, DC 20024 USA

来源：

NPJ VACCINES | 2023年 / 8卷 / 01期

基金：

英国惠康基金; 美国国家卫生研究院; 比尔及梅琳达.盖茨基金会;

关键词：

INFLUENZA; PROTECTS; IMMUNIZATION; DESIGN; SAFETY; MICE;

D O I：

10.1038/s41541-023-00654-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

On November 7th and 8th, 2022, The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), The Coalition for Epidemic Preparedness Innovation (CEPI), The Bill & Melinda Gates Foundation (BMGF), The Biomedical Advanced Research and Development Authority (BARDA), and the Wellcome Trust hosted a virtual workshop entitled "Mucosal Vaccines for SARS-CoV-2: Scientific Gaps and Opportunities." During the workshop, researchers and vaccine developers from around the world discussed the potential of mucosal vaccines to block SARS-CoV-2 transmission and reviewed the status of SARS-CoV-2 mucosal vaccine research. Here, we summarize key challenges and opportunities in basic, translational, and clinical research that were highlighted during the meeting. We also provide recommendations to advance the field and accelerate the development of mucosal vaccines for SARS-CoV-2.

引用

页数：7

共 87 条

[1]

ACM Biolabs, OP LAB RAND DOS ROUT

[2] Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2 [J].

Afkhami, Sam ;

D'Agostino, Michael R. ;

Zhang, Ali ;

Stacey, Hannah D. ;

Marzok, Art ;

Kang, Alisha ;

Singh, Ramandeep ;

Bavananthasivam, Jegarubee ;

Ye, Gluke ;

Luo, Xiangqian ;

Wang, Fuan ;

Ang, Jann C. ;

Zganiacz, Anna ;

Sankar, Uma ;

Kazhdan, Natallia ;

Koenig, Joshua F. E. ;

Phelps, Allyssa ;

Gameiro, Steven F. ;

Tang, Shangguo ;

Jordana, Manel ;

Wan, Yonghong ;

Mossman, Karen L. ;

Jeyanathan, Mangalakumari ;

Gillgrass, Amy ;

Medina, Maria Fe C. ;

Smaill, Fiona ;

Lichty, Brian D. ;

Miller, Matthew S. ;

Xing, Zhou .

CELL, 2022, 185 (05) :896-+

[3]

[Anonymous], 2022, ACS NANO, DOI [10.1021/acsnano.2c06350?fig=tgr1&ref=pdf, DOI 10.1021/ACSNANO.2C06350?FIG=TGR1&REF=PDF]

[4]

[Anonymous], 2023, IMAGINE ORAL VACCINE

[5]

[Anonymous], 2020, SBIR PHAS I DEV OR R

[6] Retrospective, Observational Studies for Estimating Vaccine Effects on the Secondary Attack Rate of SARS-CoV-2 [J].

Bannick, Marlena S. ;

Gao, Fei ;

Brown, Elizabeth R. ;

Janes, Holly E. .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2023, 192 (06) :1016-1028

[7]

Bharat Biotech International Limited, 2022, PHAS 3 RAND OP LAB M

[8]

Bharat Biotech International Limited, 2022, PHAS 3 RAND MULT OP

[9] SARS-CoV-2 viral load is associated with risk of transmission to household and community contacts [J].

Bhavnani, Darlene ;

James, Emily R. ;

Johnson, Kaitlyn E. ;

Beaudenon-Huibregtse, Sylvie ;

Chang, Patrick ;

Rathouz, Paul J. ;

Weldon, Minda ;

Matouschek, Andreas ;

Young, Amy E. .

BMC INFECTIOUS DISEASES, 2022, 22 (01)

[10]

bluewillow, 2022, BLUEWILLOW BIOL VACC

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